Electrophysiology dataset describing function of hERG potassium channels expressed in HEK cells

Abstract

High-throughput patch clamp electrophysiology dataset acquired on Nanion syncropatch 384PE platform describing voltage dependent gating of hERG potassium channels expressed in HEK cells. Specific voltage protocols: 1) Steady state activation 2) Steady state deactivation 3) Onset of inactivation This example dataset accompanies the methods paper: Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology by Chai-Ann Ng, Jessica Farr, Paul Young, Monique J. Windley, Matthew D. Perry, Adam P Hill, View ORCID ProfileJamie I Vandenberg. Preprint available at : https://doi.org/10.1101/2021.02.02.427891