MCO study tumour collection

Access & Terms of Use
metadata only access
Copyright: University of New South Wales
Access to the data is subject to originating data custodian and ethical restrictions. Ethics committee approval and other access conditions apply.
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Abstract
The MCO study is a prospective collection of tissues and clinicopathological data from over 1500 individuals undergoing curative resection for colorectal cancer from 1994 to 2010.Clinical and pathological data has been collected on all cases, including clinical follow-up to 5 years collected annually. This data is stored in a relational database, along with key genetic data on all cases, including microsatellite instability and CIMP status, mutation analysis for BRAF and KRAS, and immunohistochemical assessment of tumours. Originating source(s): MCO research group, UNSW (1993-2011)
Persistent link to this record
http://hdl.handle.net/1959.4/004_145
DOI
https://doi.org/10.4225/53/5559205bea135
Link to External Data Repository
Electronic Location
Contact Information
Access type: Access by request. Contact the Information Officer for more information: info.acp@unsw.edu.au
Research Data Creator(s)
Corporate/Industry Contributor(s)
Adult Cancer Program, Lowy Cancer Research Centre
Publication Year
2011
Resource Type
Dataset
Keyword(s)
Cancer oncology
Colorectal cancer
Mutation analysis
Immunohistochemical assessment
UNSW Faculty
Related dataset(s)
MCO study whole slide image collection
Dataset
The MCO study whole slide image collection consists of 1500 digitised tissue slides of colorectal cancers. From 1994 to 2010, the Molecular and Cellular Oncology (MCO) Study group conducted a study of individuals undergoing treatment for colorectal cancer. For the study, they systematically collected tissue samples and clinical and pathological information from more than 1500 people who had tumours surgically removed from their large bowel. This collection represents one typical section from each tumour case, stained with Hematoxylin and eosin, and scanned using a x40 objective. The resolution of the digitised images approaches that visible under an optical microscope - more than 100,000 dpi. At this resolution, each image is around 2 Gigabytes, bringing the size of the 1500 images in the MCO Whole Slide Image Collection to 3 Terabytes. The MCO whole slide image collection is now available on the Intersect Australia Research Data Storage Infrastructure (RDSI) Node. Originating source(s): MCO research group, UNSW (1993-2011)
Related publication(s)
RAD21 cohesin overexpression is a prognostic and predictive marker exacerbating poor prognosis in KRAS mutant colorectal carcinomas. dx.doi.org/10.1038/bjc.2014.31
Tolerance of Whole-Genome Doubling Propagates Chromosomal Instability and Accelerates Cancer Genome Evolution. dx.doi.org/10.1158/2159-8290.CD-13-0285
Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations. dx.doi.org/10.1038/ajg.2013.292
PIK3CA and PTEN Gene and Exon Mutation-Specific Clinicopathologic and Molecular Associations in Colorectal Cancer. dx.doi.org/10.1158/1078-0432.CCR-12-3614
Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct (beta)-catenin signalling thresholds for tumourigenesis. dx.doi.org/10.1038/onc.2012.486
Related grant(s)
Molecular and Cellular Oncology (MCO) Study
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