Data set for "AMPK activators have compound and concentration-specific effects on brain metabolism"

Abstract

Dataset consists of NMR spectra with integrals, plus excel spreadsheets containing calculations and protein concentrations for the experiments described in the manuscript "AMPK activators have compound and concentration-specific effects on brain metabolism" published in The Journal of Neurochemistry in 2023. The NMR spectra are in Bruker format and are processed with integrals. Each sample has three spectra recorded sequentially; a fully relaxed 1H spectrum, a fully relaxed 13C-decoupled 1H spectrum and a 1H-decoupled 13C NMR spectrum. Control samples (N = 4) are first, followed by 4 samples at EC50 and 4 samples at 10 x EC 50 apart from Metformin which also has an extra 4 intermediate samples. The spreadsheets contain integrals and calculations of values including relaxation compensation factors, protein concentrations and reference to the formate standard at 2 mM.