Abstract
This thesis assessed patterns of amphetamine-type-stimulants (ATS) use and their association with condomless anal
intercourse (CAI), HIV infection and mental health issues, particularly depression, among men who have sex with
men (MSM) in Vietnam. The thesis employed a socio-ecological framework with a community-based survey
conducted in 2014 in Hanoi and Ho Chi Minh City, Vietnam and a systematic review and meta-analysis of the
relationship between ATS use and HIV infection in MSM. A substantial proportion of Vietnamese men (30.4%) had
used ATS and 20.3% had used ATS recently. Methamphetamine was the most popular substance. The majority of
recent methamphetamine and ecstasy users were classified as moderate to high-risk users, according to WHO
guidelines. Methamphetamine use was associated with higher sexual sensation seeking, engagement in recent sex
work and the perception that methamphetamine use was popular among other MSM. A high prevalence of CAI with
male partners in the last three months (75.7%) was reported. CAI was associated with methamphetamine use before
or during sex, higher sexual sensation seeking, and belief in the safety of withdrawal as an HIV prevention strategy.
Voluntary HIV tests conducted for 210 men in Hanoi found a moderate HIV prevalence of 6.7%. Men who used
methamphetamine before or during sex, who had engaged in sex work and perceived more homosexuality-related
stigma were more likely to have an HIV positive test. A sizable proportion of men (11.3%) were classified as having
major depression which was associated with ever having used ATS and higher enacted (i.e. experienced)
homosexuality-related stigma. The systematic review and meta-analysis demonstrated a significant pooled estimate
of ATS use and HIV infection in MSM across longitudinal, case-control and cross-sectional studies, but not for
ecstasy use in cross-sectional studies. Methodological shortcomings of current studies of drug use and sexual
behaviour were identified. This thesis suggests a comprehensive HIV prevention package, that includes treatment for
methamphetamine use, is needed for MSM in Vietnam to address drug use and the risks of HIV at the individual,
community and societal levels. Recommendations for further research on drug use and sexual behaviours are
suggested, including periodic assessment of ATS use.