Oxidative damage and inflammation in the central nervous system: influence of age and specific nutritional elements

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Abstract
The studies presented in this thesis were designed to quantitate and compare the influence of age and selected dietary elements on oxidative and inflammatory activity and circulating levels of the essential pyridine nucleotide nicotinamide adenine dinucleotide (NAD+), in the human systemic circulation and central nervous system (CNS). The data presented shows significant associations between aging and a progressive increase in oxidative and inflammatory processes concomitant with a reduction in NAD+ availability both systemically and within the CNS, even in the absence of disease. Evidence is further provided indicating that these biochemical changes may be exacerbated by consumption of alcohol or foods high in animal derived saturated fat and refined carbohydrates. Carotenoids, cobalamin (vitamin B12) and folate were also found to effect NAD+ levels and modulate oxidative and inflammatory processes. Considered together the evidence presented in this thesis suggests that oxidative and inflammatory activity, processes associated with aging and degenerative disease, can be influenced by dietary choices and that nutritional intervention may confer protection against age-related deficits, particularly in the central nervous system.
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Author(s)
Guest, Jade
Supervisor(s)
Grant, Ross
Bilgin, Ayse
Garg, Manohar
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Publication Year
2015
Resource Type
Thesis
Degree Type
PhD Doctorate
UNSW Faculty
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