Publication:
Combining Imagination and Reason in the Treatment of Depression: A Randomized Controlled Trial of Internet-Based Cognitive-Bias Modification and Internet-CBT for Depression

dc.contributor.author Williams, Alishia en_US
dc.contributor.author Blackwell, Simon en_US
dc.contributor.author Mackenzie, Anna en_US
dc.contributor.author Holmes, Emily en_US
dc.contributor.author Andrews, Gavin en_US
dc.date.accessioned 2021-11-25T12:27:07Z
dc.date.available 2021-11-25T12:27:07Z
dc.date.issued 2013 en_US
dc.description.abstract Objective: Computerized cognitive-bias modification (CBM) protocols are rapidly evolving in experimental medicine yet might best be combined with Internet-based cognitive behavioral therapy (iCBT). No research to date has evaluated the combined approach in depression. The current randomized controlled trial aimed to evaluate both the independent effects of a CBM protocol targeting imagery and interpretation bias (CBM-I) and the combined effects of CBM-I followed by iCBT. Method: Patients diagnosed with a major depressive episode were randomized to an 11-week intervention (1 week/CBM-I +10 weeks/iCBT; n = 38) that was delivered via the Internet with no face-to-face patient contact or to a wait-list control (WLC; n = 31). Results: Intent-to-treat marginal models using restricted maximum likelihood estimation demonstrated significant reductions in primary measures of depressive symptoms and distress corresponding to medium-large effect sizes (Cohen’s d = 0.62–2.40) following CBM-I and the combined (CBM-I + iCBT) intervention. Analyses demonstrated that the change in interpretation bias at least partially mediated the reduction in depression symptoms following CBM-I. Treatment superiority over the WLC was also evident on all outcome measures at both time points (Hedges gs = .59 –.98). Significant reductions were also observed following the combined intervention on secondary measures associated with depression: disability, anxiety, and repetitive negative thinking (Cohen’s d = 1.51–2.23). Twenty-seven percent of patients evidenced clinically significant change following CBM-I, and this proportion increased to 65% following the combined intervention. Conclusions: The current study provides encouraging results of the integration of Internet-based technologies into an efficacious and acceptable form of treatment delivery. en_US
dc.identifier.uri http://hdl.handle.net/1959.4/52717
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/3.0/au/ en_US
dc.source Legacy MARC en_US
dc.subject.other major depressive disorder en_US
dc.subject.other cognitive-bias modification (CBM) en_US
dc.subject.other Internet-based cognitive behavioral therapy (iCBT) en_US
dc.subject.other depression en_US
dc.subject.other interpretation bias en_US
dc.subject.other mental imagery en_US
dc.title Combining Imagination and Reason in the Treatment of Depression: A Randomized Controlled Trial of Internet-Based Cognitive-Bias Modification and Internet-CBT for Depression en_US
dc.type Journal Article en
dcterms.accessRights open access
dspace.entity.type Publication en_US
unsw.accessRights.uri https://purl.org/coar/access_right/c_abf2
unsw.description.publisherStatement This article has been published under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s). Author(s) grant(s) the American Psychological Association the exclusive right to publish the article and identify itself as the original publisher. en_US
unsw.identifier.doiPublisher http://dx.doi.org/10.1037/a0033247 en_US
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofjournal Journal of Consulting and Clinical Psychology en_US
unsw.relation.originalPublicationAffiliation Williams, Alishia, Psychiatry, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Blackwell, Simon, MRC Cognition and Brain Sciences Unit en_US
unsw.relation.originalPublicationAffiliation Mackenzie, Anna, Psychiatry, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Holmes , Emily, MRC Cognition and Brain Sciences Unit en_US
unsw.relation.originalPublicationAffiliation Andrews, Gavin, Psychiatry, Faculty of Medicine, UNSW en_US
unsw.relation.school School of Psychiatry *
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