Publication:
Anterior Cingulate Integrity: Executive and Neuropsychiatric Features in Parkinson’s Disease

dc.contributor.author Lewis, Simon JG en_US
dc.contributor.author Shine, James M en_US
dc.contributor.author Duffy, Shantel en_US
dc.contributor.author Halliday, Glenda en_US
dc.contributor.author Naismith, Sharon L en_US
dc.date.accessioned 2021-11-25T12:29:29Z
dc.date.available 2021-11-25T12:29:29Z
dc.date.issued 2012 en_US
dc.description.abstract Patients with advanced Parkinson’s Disease (PD) commonly suffer with significant executive dysfunction and concomitant visual hallucinations. Although the underlying pathophysiology remains poorly understood, numerous studies have highlighted the strong association between these neuropsychiatric features suggesting that they may share common neural pathways. Whilst previous neuroimaging studies have identified widespread volume loss across a number of cortical regions, to date no studies have utilised Proton Magnetic Resonance Spectroscopy (MRS) to provide insights into how neurometabolic changes may relate to such symptoms. In this study, twenty patients underwent MRS to determine the N-Acetyl Aspartate/Creatine ratio, which reflects the degree of neuronal integrity in neurodegenerative diseases. Voxels were obtained from a test region within the anterior cingulate cortex, an area critical for a wide range of executive mechanisms as well as from a control volume in the posterior cingulate cortex. Lower N-Acetyl Aspartate/Creatine ratios in the anterior but not the posterior cingulate cortex significantly correlated with poorer executive function on tasks of attentional set-shifting and response inhibition. In addition, lower levels of this metabolite were associated with more severe psychotic symptoms (as measured by the Scales for Outcomes in Parkinson's disease-Psychiatric Complications) and poorer performance on the bistable percept paradigm, a recently developed neuropsychological probe of visual hallucinations in PD. Levels of N-Acetyl Aspartate/Creatine were significantly lower in hallucinators compared to non-hallucinators within the anterior cingulate cortex but did not differ in the posterior cingulate cortex. These results suggest that loss of neuronal integrity within the anterior cingulate cortex plays an important role in the pathophysiology underlying executive functioning and visual hallucinations in PD. en_US
dc.identifier.issn 0022-3050 en_US
dc.identifier.uri http://hdl.handle.net/1959.4/53621
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/3.0/au/ en_US
dc.source Legacy MARC en_US
dc.subject.other hallucinations en_US
dc.subject.other Parkinson disease en_US
dc.subject.other anterior cingulate en_US
dc.title Anterior Cingulate Integrity: Executive and Neuropsychiatric Features in Parkinson’s Disease en_US
dc.type Journal Article en
dcterms.accessRights open access
dspace.entity.type Publication en_US
unsw.accessRights.uri https://purl.org/coar/access_right/c_abf2
unsw.identifier.doiPublisher http://dx.doi.org/10.1002/mds.25104 en_US
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofissue 10 en_US
unsw.relation.ispartofjournal Movement Disorders en_US
unsw.relation.ispartofpagefrompageto 1262-1267 en_US
unsw.relation.ispartofvolume 27 en_US
unsw.relation.originalPublicationAffiliation Lewis, Simon JG, Ageing Brain Center, Brain and Mind Research Institute, The University of Sydney, Sydney, New South Wales, Australia en_US
unsw.relation.originalPublicationAffiliation Shine, James M, Ageing Brain Center, Brain and Mind Research Institute, The University of Sydney, Sydney, New South Wales, Australia en_US
unsw.relation.originalPublicationAffiliation Duffy, Shantel, Ageing Brain Center, Brain and Mind Research Institute, The University of Sydney, Sydney, New South Wales, Australia en_US
unsw.relation.originalPublicationAffiliation Halliday, Glenda, Neuroscience Research Australia, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Naismith, Sharon L, Ageing Brain Center, Brain and Mind Research Institute, The University of Sydney, Sydney, New South Wales, Australia en_US
unsw.relation.school Neuroscience Research Australia *
unsw.subject.fieldofresearchcode 110903 Central Nervous System en_US
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