Distribution of pathology in frontal variant Alzheimer’s disease Blennerhassett, Richard en_US Lillo, Patricia en_US Halliday, Glenda en_US Hodges, John R en_US Kril, Jillian J en_US 2021-11-25T12:29:07Z 2021-11-25T12:29:07Z 2014 en_US
dc.description.abstract Atypical presentations of Alzheimer’s disease (AD) have been described, including a “frontal” variant (fvAD), which presents with personality change and executive dysfunction similar to that seen in behavioral variant frontotemporal dementia (bvFTD). This clinical variation is thought to reflect the regional distribution of pathology, although few reports include autopsy confirmation. We compared three clinicopathological groups matched for age at diagnosis and disease duration; those with possible bvFTD who at autopsy had only AD (fvAD), those with typical AD clinically and pathologically, and those with typical clinical bvFTD confirmed pathologically. The density of neurons and AD-type pathology was quantified in the frontal association, occipital association, and entorhinal cortices and hippocampal CA1 regions. Immunohistochemistry for phosphorylated tau and amyloid-β deposition was used to detect neurofibrillary tangles and plaques. Of the six core clinical features of the International Consensus Criteria, disinhibition, stereotyped behaviors and executive dysfunction were most common, occurring in five of the six fvAD patients. Other features were rare. While there was no significant difference in neuron density between groups for any of the four regions, when the ratio of frontal:occipital pathology was examined, neuronal density in fvAD was significantly less than AD but similar to bvFTD. The frontal:occipital ratio of AD-type pathology was also greater in fvAD than AD. The findings of this study suggest a frontal variant of AD exists with features that mimic bvFTD and that this reflects a differential distribution of neurodegeneration with more marked pathology in the frontal cortex compared with the occipital cortex. en_US
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.subject.other amyloid-β plaques en_US
dc.subject.other neuronal loss en_US
dc.subject.other neurofibrillary tangles en_US
dc.title Distribution of pathology in frontal variant Alzheimer’s disease en_US
dc.type Journal Article en
dcterms.accessRights open access
dspace.entity.type Publication en_US
unsw.identifier.doiPublisher en_US
unsw.relation.FunderRefNo GNT1037746 en_US
unsw.relation.FunderRefNoURL en_US
unsw.relation.faculty Medicine & Health
unsw.relation.fundingScheme NHMRC Program en_US
unsw.relation.ispartofissue 1 en_US
unsw.relation.ispartofjournal Journal of Alzheimer’s disease en_US
unsw.relation.ispartofpagefrompageto 63-70 en_US
unsw.relation.ispartofvolume 39 en_US
unsw.relation.originalPublicationAffiliation Blennerhassett, Richard, Disciplines of Pathology, Sydney Medical School en_US
unsw.relation.originalPublicationAffiliation Lillo, Patricia, NeuRA en_US
unsw.relation.originalPublicationAffiliation Halliday, Glenda, Neuroscience Research Australia, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Hodges, John R, Neuroscience Research Australia, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Kril, Jillian J, Disciplines of Pathology and Medicine, Sydney Medical School en_US Neuroscience Research Australia *
unsw.subject.fieldofresearchcode 110903 Central Nervous System en_US
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