Biomarkers and Biologics in Chronic Rhinosinusitis

ac.person.orcid 0000-0002-2765-8684
ac.person.orcid 0000-0002-6942-8975
ac.person.orcid 0000-0002-3586-8761
ac.person.position HDR Student
ac.person.position Staff
ac.person.position Staff
dc.contributor.advisor Harvey, Richard
dc.contributor.advisor Sewell, William Ho, Jacqueline 2022-04-21T01:40:46Z 2022-04-21T01:40:46Z 2022
dc.description.abstract Eosinophilic chronic rhinosinusitis (eCRS) or type 2 dominant chronic rhinosinusitis (CRS) is a complex inflammatory disease mediated by type-2 cytokines, including interleukin (IL)-5. Management of this condition is often difficult, requiring multimodal approaches with local and systemic medications as well as surgical therapy. Biologic therapies, including mepolizumab (a monoclonal antibody targeting IL-5), have been successfully used in eosinophilic asthma and are emerging as a new treatment in CRS and eCRS, however there is limited data in this field. This thesis focuses on biomarkers and biologics in CRS. Firstly, identifying and assessing clinical biomarkers that are available to the guide management in patients with CRS and eCRS. Secondly, a prospective open-label single-arm single-centre study of the effectiveness of mepolizumab in patients with eCRS was performed. In this study, biomarkers as well as clinical, functional, and patient reported outcomes are assessed to determine the utility of mepolizumab as biologic treatment for eCRS.
dc.language English
dc.language.iso en
dc.publisher UNSW, Sydney
dc.rights CC BY 4.0
dc.subject.other Chronic rhinosinusitis
dc.subject.other Eosinophils
dc.subject.other Biomarkers
dc.subject.other Biologics
dc.subject.other Eosinophilic chronic rhinosinusitis
dc.subject.other ENT Surgery
dc.subject.other Otorhinolaryngology
dc.title Biomarkers and Biologics in Chronic Rhinosinusitis
dc.type Thesis
dcterms.accessRights embargoed access
dcterms.rightsHolder Ho, Jacqueline
dspace.entity.type Publication
unsw.accessRights.uri 2024-04-21 2022-04-20
unsw.description.embargoNote Embargoed until 2024-04-21
unsw.relation.faculty Medicine & Health Clinical School St Vincents Hospital Clinical School St Vincents Hospital Clinical School St Vincents Hospital
unsw.subject.fieldofresearchcode 320217 Otorhinolaryngology
unsw.subject.fieldofresearchcode 3204 Immunology
unsw.thesis.degreetype PhD Doctorate
Resource type