Publication:
Unveiling the Bmp13 enigma: Redundant morphogen or crucial regulator?

dc.contributor.author Williams, Lisa en_US
dc.contributor.author Bhargav, Divya en_US
dc.contributor.author Diwan, Ashish en_US
dc.date.accessioned 2021-11-25T15:32:12Z
dc.date.available 2021-11-25T15:32:12Z
dc.date.issued 2008 en_US
dc.description.abstract Bone morphogenetic proteins are a diverse group of morphogens with influences not only on bone tissue, as the nomenclature suggests, but on multiple tissues in the body and often at crucial and influential periods in development. The purpose of this review is to identify and discuss current knowledge of one vertebrate BMP, Bone Morphogenetic Protein 13 (BMP13), from a variety of research fields, in order to clarify BMP13's functional contribution to developing and maintaining healthy tissues, and to identify potential future research directions for this intriguing morphogen. BMP13 is highly evolutionarily conserved (active domain >95%) across diverse species from Zebrafish to humans, suggesting a crucial function. In addition, mutations in BMP13 have recently been associated with Klippel-Feil Syndrome, causative of numerous skeletal and developmental defects including spinal disc fusion. The specific nature of BMP13's crucial function is, however, not yet known. The literature for BMP13 is focused largely on its activity in the healing of tendon-like tissues, or in comparisons with other BMP family molecules for whom a clear function in embryo development or osteogenic differentiation has been identified. There is a paucity of detailed information regarding BMP13 protein activity, structure or protein processing. Whilst some activity in the stimulation of osteogenic or cartilaginous gene expression has been reported, and BMP13 expression is found in post natal cartilage and tendon tissues, there appears to be a redundancy of function in the BMP family, with several members capable of stimulating similar tissue responses. This review aims to summarise the known or potential role(s) for BMP13 in a variety of biological systems. en_US
dc.description.uri http://www.biolsci.org/v04p0318.htm en_US
dc.identifier.issn 1449-2288 en_US
dc.identifier.uri http://hdl.handle.net/1959.4/44689
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/3.0/au/ en_US
dc.source Legacy MARC en_US
dc.subject.other BMP13 en_US
dc.subject.other cartilage en_US
dc.subject.other growth factor en_US
dc.subject.other development en_US
dc.subject.other bone en_US
dc.title Unveiling the Bmp13 enigma: Redundant morphogen or crucial regulator? en_US
dc.type Journal Article en
dcterms.accessRights open access
dspace.entity.type Publication en_US
unsw.accessRights.uri https://purl.org/coar/access_right/c_abf2
unsw.description.publisherStatement Copyright ©2010 Ivyspring International Publisher. en_US
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofissue 5 en_US
unsw.relation.ispartofjournal International Journal of Biological Sciences en_US
unsw.relation.ispartofpagefrompageto 318-329 en_US
unsw.relation.ispartofvolume 4 en_US
unsw.relation.originalPublicationAffiliation Williams, Lisa, Clinical School - St George Hospital, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Bhargav, Divya, Clinical School - St George Hospital, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Diwan, Ashish, Clinical School - St George Hospital, Faculty of Medicine, UNSW en_US
unsw.relation.school Clinical School St George Hospital *
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