CD103+ intraepithelial lymphocytes - A unique population in microsatellite unstable sporadic colorectal cancer Quinn, E en_US Hawkins, Nicholas en_US Yip, Yl en_US Suter, C en_US Ward, Robyn en_US 2021-11-25T13:30:18Z 2021-11-25T13:30:18Z 2003 en_US
dc.description.abstract Colorectal cancers with microsatellite instability (MSI) typically show increased numbers of intraepithelial lymphocytes (IEL) in comparison to microsatellite stable (MSS) cancers. The aim of this study was to determine the phenotype of this unique lymphocyte population in MSI and MSS colorectal cancers. Twenty-four individuals with sporadic colorectal cancer (17 MSI, 7 MSS) were included in this study. Intraepithelial and stromal lymphocytes were detected using immunohistochemistry with anti-CD8 and anti-CD103 antibodies, and two observers independently quantified the numbers of lymphocytes. CD103+ (αEβ7+) IELs detected within tumour tissue co-expressed CD8+ while the stromal lymphocytes were phenotypically heterogeneous, with respect to CD8+ and CD103+ expression. MSI colorectal cancers harboured increased numbers of CD8+CD103+ IELs, as well as CD8+CD103− and CD8+CD103+ stromal lymphocytes, when compared with MSS colorectal cancers. CD103+ IELs were found at 27-fold greater numbers in the tumour epithelium than in normal epithelium from the same patient (P=0.001, Wilcoxon matched pairs test). From our findings, we have proposed a mechanism for the homing of these αEβ7+ lymphocytes to tumour tissue in MSI and MSS colorectal cancers. en_US
dc.identifier.issn 0959-8049 en_US
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.title CD103+ intraepithelial lymphocytes - A unique population in microsatellite unstable sporadic colorectal cancer en_US
dc.type Journal Article en
dcterms.accessRights metadata only access
dspace.entity.type Publication en_US
unsw.identifier.doiPublisher en_US
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofjournal Eur J Cancer en_US
unsw.relation.ispartofpagefrompageto 469-475 en_US
unsw.relation.ispartofvolume 39 en_US
unsw.relation.originalPublicationAffiliation Quinn, E en_US
unsw.relation.originalPublicationAffiliation Hawkins, Nicholas, Medical Sciences, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Yip, Yl en_US
unsw.relation.originalPublicationAffiliation Suter, C en_US
unsw.relation.originalPublicationAffiliation Ward, Robyn, Clinical School - St Vincent's Hospital, Faculty of Medicine, UNSW en_US School of Medical Sciences * Clinical School St Vincents Hospital *
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