Publication:
Circumcision and risk of HIV infection in Australian homosexual men

dc.contributor.author Mao, Limin en_US
dc.contributor.author Prestage, Garrett en_US
dc.contributor.author Donovan, Basil en_US
dc.contributor.author Imrie, John en_US
dc.contributor.author Kippax, Susan en_US
dc.contributor.author Kaldor, John en_US
dc.contributor.author Grulich, Andrew en_US
dc.contributor.author Templeton, David en_US
dc.contributor.author Jin, Feng Yi en_US
dc.date.accessioned 2021-11-25T15:43:20Z
dc.date.available 2021-11-25T15:43:20Z
dc.date.issued 2009 en_US
dc.description.abstract Objective: To assess circumcision status as a risk factor for HIV seroconversion in homosexual men. Design, setting and participants: The Health in Men (HIM) study was a prospective cohort of homosexual men in Sydney, Australia. HIV-negative men (n = 1426) were recruited primarily from community-based sources between 2001 and 2004 and followed to mid-2007. Participants underwent annual HIV testing, and detailed information on sexual risk behaviour was collected every 6 months. Main outcome measure: HIV incidence in circumcised compared with uncircumcised participants, stratified by whether or not men predominantly practised the insertive role in anal intercourse. Results: There were 53 HIV seroconversions during follow-up; an incidence of 0.78 per 100 person-years. On multivariate analysis controlling for behavioural risk factors, being circumcised was associated with a nonsignificant reduction in risk of HIV seroconversion [hazard ratio 0.78, 95% confidence interval (CI) 0.42-1.45, P = 0.424]. Among one-third of study participants who reported a preference for the insertive role in anal intercourse, being circumcised was associated with a significant reduction in HIV incidence after controlling for age and unprotected anal intercourse (UAI) (hazard ratio 0.11, 95% CI 0.03-0.80, P = 0.041). Those who reported a preference for the insertive role overwhelmingly practised insertive rather than receptive UAI. Conclusions: Overall, circumcision did not significantly reduce the risk of HIV infection in the HIM cohort. However, it was associated with a significant reduction in HIV incidence among those participants who reported a preference for the insertive role in anal intercourse. Circumcision may have a role as an HIV prevention intervention in this subset of homosexual men. en_US
dc.identifier.issn 0269-9370 en_US
dc.identifier.uri http://hdl.handle.net/1959.4/44924
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/3.0/au/ en_US
dc.source Legacy MARC en_US
dc.subject.other CLINICAL SCIENCES (FORC:110300) en_US
dc.subject.other risk factors en_US
dc.subject.other homosexual men en_US
dc.subject.other HIV en_US
dc.subject.other circumcision en_US
dc.subject.other risk behaviour en_US
dc.title Circumcision and risk of HIV infection in Australian homosexual men en_US
dc.type Journal Article en
dcterms.accessRights metadata only access
dspace.entity.type Publication en_US
unsw.accessRights.uri http://purl.org/coar/access_right/c_14cb
unsw.description.notePublic Published by Lippincott Williams & Wilkins, Philadelphia, PA, USA en_US
unsw.identifier.doiPublisher http://dx.doi.org/10.1097/QAD.0b013e32833202b8 en_US
unsw.relation.faculty Arts Design & Architecture
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofissue 17 en_US
unsw.relation.ispartofjournal AIDS en_US
unsw.relation.ispartofpagefrompageto 2347-2351 en_US
unsw.relation.ispartofvolume 23 en_US
unsw.relation.originalPublicationAffiliation Mao, Limin, National Centre in HIV Social Research, Faculty of Arts & Social Sciences, UNSW en_US
unsw.relation.originalPublicationAffiliation Prestage, Garrett, National Centre in HIV Epidemiology & Clinical Research, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Donovan, Basil, National Centre in HIV Epidemiology & Clinical Research, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Imrie, John, National Centre in HIV Social Research, Faculty of Arts & Social Sciences, UNSW en_US
unsw.relation.originalPublicationAffiliation Kippax, Susan, National Centre in HIV Social Research, Faculty of Arts & Social Sciences, UNSW en_US
unsw.relation.originalPublicationAffiliation Kaldor, John, National Centre in HIV Epidemiology & Clinical Research, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Grulich, Andrew, National Centre in HIV Epidemiology & Clinical Research, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Templeton, David, National Centre in HIV Epidemiology & Clinical Research, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Jin, Feng Yi, National Centre in HIV Epidemiology & Clinical Research, Faculty of Medicine, UNSW en_US
unsw.relation.school Centre for Social Research in Health *
unsw.relation.school The Kirby Institute *
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