Surface water toxicity assessment by ecotoxicological and in vitro toxicologocical assays Khalil, Christian en_US Winder, C. en_US
dc.contributor.other Kungolos, A.G en_US
dc.contributor.other Brebbia, C.A en_US
dc.contributor.other Samaras, C.P en_US
dc.contributor.other Popov, V en_US 2021-11-25T13:21:58Z 2021-11-25T13:21:58Z 2008 en_US
dc.description.abstract Environmental pollution is an ever-growing problem in today's consumer world. Disposal of chemicals and their unwanted by-products into the natural environment poses significant risks to ecosystems and human health. The receiving natural environment is a sink to chemical mixtures and this triggers a range of potential environmental and health problems. It is therefore imperative to develop rapid reliable techniques for initial screening and establishment of toxic potential and risks. The selection of the catchment study locations in Tasmania (creeks stream and rivers) was the result of recorded observations following rainfall of anomalous oyster population mortality and adverse human health in the geographical catchment area. A biological impact was identified in the study area but the casual agents and environmental triggers were unclear hence the need for in vitro toxicology assessment techniques for identifying the triggers and risks associated with exposure to environmental contaminants. The aim of this paper is to present findings of in vitro cytotoxicity assays and their potential in assessing contaminated river water toxicity using human cell cultures. The key to the approach adopted was to investigate exposure to the environmental pollutants and generate human toxicity profiles with a high degree of confidence using cell viability and damage as end points. Furthermore, correlation of the toxicity results using human cell cultures as ecological receptors in the study area clearly indicated the usefulness of and sensitivity of human-derived cells in detecting the toxicity of unknown chemical mixtures. en_US
dc.identifier.isbn 9781845641146 en_US
dc.language English
dc.language.iso EN en_US
dc.publisher WIT Press en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.title Surface water toxicity assessment by ecotoxicological and in vitro toxicologocical assays en_US
dc.type Book Chapter en
dcterms.accessRights metadata only access
dspace.entity.type Publication en_US
unsw.identifier.doiPublisher en_US Southampton, Boston en_US
unsw.relation.faculty Science
unsw.relation.ispartofpagefrompageto 253-262 en_US
unsw.relation.ispartoftitle Environmental Toxicology en_US
unsw.relation.originalPublicationAffiliation Khalil, Christian, Safety Science, Faculty of Science, UNSW en_US
unsw.relation.originalPublicationAffiliation Winder, C. en_US School of Risk & Safety Science *
Resource type