Bacterial quorum sensing and interference by naturally occurring biomimics McDougald, Diane en_US Rice, Scott A. en_US Kjelleberg, Staffan en_US 2021-11-25T13:07:13Z 2021-11-25T13:07:13Z 2007 en_US
dc.description.abstract Bacteria are able to coordinate gene expression as a community through the secretion and detection of signalling molecules so that the members of the community can simultaneously express specific behaviours. This mechanism of regulation of behaviour appears to be a key trait for adaptation to specific environments and has been shown to regulate a variety of important phenotypes, from virulence factor production to biofilm formation to symbiosis related behaviours such as bioluminescence. The ability to communicate and communally regulate gene expression is hypothesised to have evolved as a way for organisms to delay expression of phenotypes until numerical supremacy is reached. For example, in the case of infection, if an invading microorganism were to express virulence factors too early, the host may be able to mount a successful defence and repel the invaders. There is growing evidence that bacterial quorum sensing (QS) systems are involved in cross-kingdom signalling with eukaryotic organisms and that eukaryotes are capable of actively responding to bacteria in their environment by detecting and acting upon the presence of these signalling molecules. Likewise, eukaryotes produce compounds that can interfere with QS systems in bacteria by acting as agonists or antagonists. An exciting new field of study, biomimetics, takes inspiration from nature’s models and attempts to design solutions to human problems, and biomimics of QS systems may be one such solution. This article presents the acylated homoserine lactone and autoinducer 2 QS systems in bacteria, the means of intercepting or interfering with bacterial QS systems evolved by eukaryotes, and the rational design of synthetic antagonists. en_US
dc.identifier.issn 1618-2642 en_US
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.subject.other virulence en_US
dc.subject.other quorum sensing en_US
dc.subject.other autoinducer 2 en_US
dc.subject.other biomimic en_US
dc.subject.other quorum sensing antagonist en_US
dc.subject.other AHL en_US
dc.title Bacterial quorum sensing and interference by naturally occurring biomimics en_US
dc.type Journal Article en
dcterms.accessRights metadata only access
dspace.entity.type Publication en_US
unsw.description.publisherStatement The original publication is available at en_US
unsw.identifier.doiPublisher en_US
unsw.relation.faculty Science
unsw.relation.ispartofissue 2 en_US
unsw.relation.ispartofjournal Analytical and Bioanalytical Chemistry en_US
unsw.relation.ispartofpagefrompageto 445-453 en_US
unsw.relation.ispartofvolume 387 en_US
unsw.relation.originalPublicationAffiliation McDougald, Diane, Centre for Marine Biofouling & Bioinnovation, UNSW en_US
unsw.relation.originalPublicationAffiliation Rice, Scott A., Centre for Marine Biofouling & Bioinnovation, UNSW en_US
unsw.relation.originalPublicationAffiliation Kjelleberg, Staffan, Centre for Marine Biofouling & Bioinnovation, UNSW en_US School of Biological, Earth & Environmental Sciences *
Resource type