Publication:
Per-contact probability of HIV transmission in homosexual men in Sydney in the era of HAART

dc.contributor.author Jin, Feng Yi en_US
dc.contributor.author Jansson, James en_US
dc.contributor.author Law, Matthew en_US
dc.contributor.author Prestage, Garrett en_US
dc.contributor.author Zablotska, Iryna en_US
dc.contributor.author Imrie, John en_US
dc.contributor.author Kippax, Susan en_US
dc.contributor.author Kaldor, John en_US
dc.contributor.author Grulich, Andrew en_US
dc.contributor.author Wilson, David en_US
dc.date.accessioned 2021-11-25T16:45:22Z
dc.date.available 2021-11-25T16:45:22Z
dc.date.issued 2010 en_US
dc.description.abstract Objective: The objective of this study is to estimate per-contact probability of HIV transmission in homosexual men due to unprotected anal intercourse (UAI) in the era of HAART. Design: Data were collected from a longitudinal cohort study of community-based HIV-negative homosexual men in Sydney, Australia. Methods: A total of 1427 participants were recruited from June 2001 to December 2004. They were followed up with 6-monthly detailed behavioral interviews and annual testing for HIV till June 2007. Data were used in a bootstrapping method, coupled with a statistical analysis that optimized a likelihood function for estimating the per-exposure risks of HIV transmission due to various forms of UAI. Results: During the study, 53 HIV seroconversion cases were identified. The estimated per-contact probability of HIV transmission for receptive UAI was 1.43% [95% confidence interval (CI) 0.48–2.85] if ejaculation occurred inside the rectum, and it was 0.65% (95% CI 0.15–1.53) if withdrawal prior to ejaculation was involved. The estimated transmission rate for insertive UAI in participants who were circumcised was 0.11% (95% CI 0.02–0.24), and it was 0.62% (95% CI 0.07–1.68) in uncircumcised men. Thus, receptive UAI with ejaculation was found to be approximately twice as risky as receptive UAI with withdrawal or insertive UAI for uncircumcised men and over 10 times as risky as insertive UAI for circumcised men. Conclusion: Despite the fact that a high proportion of HIV-infected men are on antiretroviral treatment and have undetectable viral load, the per-contact probability of HIV transmission due to UAI is similar to estimates reported from developed country settings in the pre-HAART era. en_US
dc.identifier.issn 0269-9370 en_US
dc.identifier.uri http://hdl.handle.net/1959.4/50363
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/3.0/au/ en_US
dc.source Legacy MARC en_US
dc.subject.other HIV en_US
dc.subject.other Australia en_US
dc.subject.other cohort study en_US
dc.subject.other homosexuality en_US
dc.subject.other male en_US
dc.subject.other per-contact probability en_US
dc.subject.other transmission risk en_US
dc.title Per-contact probability of HIV transmission in homosexual men in Sydney in the era of HAART en_US
dc.type Journal Article en
dcterms.accessRights metadata only access
dspace.entity.type Publication en_US
unsw.accessRights.uri http://purl.org/coar/access_right/c_14cb
unsw.identifier.doiPublisher http://dx.doi.org/10.1097/QAD.0b013e3283372d90 en_US
unsw.relation.faculty Medicine & Health
unsw.relation.faculty Arts Design & Architecture
unsw.relation.ispartofissue 6 en_US
unsw.relation.ispartofjournal AIDS en_US
unsw.relation.ispartofpagefrompageto 907-913 en_US
unsw.relation.ispartofvolume 24 en_US
unsw.relation.originalPublicationAffiliation Jin, Feng Yi, National Centre in HIV Epidemiology & Clinical Research, UNSW en_US
unsw.relation.originalPublicationAffiliation Jansson, James, National Centre in HIV Epidemiology & Clinical Research, UNSW en_US
unsw.relation.originalPublicationAffiliation Law, Matthew, National Centre in HIV Epidemiology & Clinical Research, UNSW en_US
unsw.relation.originalPublicationAffiliation Prestage, Garrett, National Centre in HIV Epidemiology & Clinical Research, UNSW en_US
unsw.relation.originalPublicationAffiliation Zablotska, Iryna, National Centre in HIV Epidemiology & Clinical Research, UNSW en_US
unsw.relation.originalPublicationAffiliation Imrie, John, National Centre in HIV Social Research, UNSW en_US
unsw.relation.originalPublicationAffiliation Kippax, Susan, Social Policy Research Centre, UNSW en_US
unsw.relation.originalPublicationAffiliation Kaldor, John, National Centre in HIV Epidemiology & Clinical Research, UNSW en_US
unsw.relation.originalPublicationAffiliation Grulich, Andrew, National Centre in HIV Epidemiology & Clinical Research, UNSW en_US
unsw.relation.originalPublicationAffiliation Wilson, David, National Centre in HIV Epidemiology & Clinical Research, UNSW en_US
unsw.relation.school The Kirby Institute *
unsw.relation.school Centre for Social Research in Health *
unsw.relation.school Social Policy Research Centre *
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