Publication:
Reduced T helper and B lymphocytes in Parkinson’s disease
Reduced T helper and B lymphocytes in Parkinson’s disease
| dc.contributor.author | Stevens, Claire H | en_US |
| dc.contributor.author | Rowe, Dominic | en_US |
| dc.contributor.author | Morel-Kopp, Marie-Christine | en_US |
| dc.contributor.author | Orr, Carolyn | en_US |
| dc.contributor.author | Ranola, Madelaine | en_US |
| dc.contributor.author | Ward, Christopher | en_US |
| dc.contributor.author | Halliday, Glenda | en_US |
| dc.contributor.author | Russell, Tonia | en_US |
| dc.date.accessioned | 2021-11-25T12:28:51Z | |
| dc.date.available | 2021-11-25T12:28:51Z | |
| dc.date.issued | 2012 | en_US |
| dc.description.abstract | Gene association with HLA suggests involvement of immune mediated mechanisms in the pathogenesis of Parkinson’s disease (PD). Only a small number of studies have found differences between circulating leukocyte populations in PD patients compared to controls, with conflicting results. To clarify whether there is a circulating leukocyte PD phenotype, we assessed the numbers of T, B and natural killer cells, and monocytes and found a small reduction (15-25%) in CD4+ T and CD19+ B cells in PD. These findings suggest some compromise in immune cells in PD and have potential implications for immune function and the progression of PD. | en_US |
| dc.identifier.issn | 0165-5728 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1959.4/53347 | |
| dc.language | English | |
| dc.language.iso | EN | en_US |
| dc.rights | CC BY-NC-ND 3.0 | en_US |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/au/ | en_US |
| dc.source | Legacy MARC | en_US |
| dc.subject.other | B lymphocytes | en_US |
| dc.subject.other | Parkinson’s disease | en_US |
| dc.subject.other | T lymphocytes | en_US |
| dc.title | Reduced T helper and B lymphocytes in Parkinson’s disease | en_US |
| dc.type | Journal Article | en |
| dcterms.accessRights | open access | |
| dspace.entity.type | Publication | en_US |
| unsw.accessRights.uri | https://purl.org/coar/access_right/c_abf2 | |
| unsw.description.publisherStatement | This is the author’s version of a work that was accepted for publication in Journal of Neuroimmunology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Neuroimmunology, Vol. 252, Issue 1-2, (2012)] DOI 10.1016/j.jneuroim.2012.07.015 | en_US |
| unsw.identifier.doiPublisher | http://dx.doi.org/10.1016/j.jneuroim.2012.07.015 | en_US |
| unsw.relation.FunderRefNo | GNT0510186 | en_US |
| unsw.relation.faculty | Medicine & Health | |
| unsw.relation.faculty | Science | |
| unsw.relation.fundingScheme | NHMRC Project | en_US |
| unsw.relation.ispartofissue | 1-2 | en_US |
| unsw.relation.ispartofjournal | Journal of Neuroimmunology | en_US |
| unsw.relation.ispartofpagefrompageto | 95-99 | en_US |
| unsw.relation.ispartofvolume | 252 | en_US |
| unsw.relation.originalPublicationAffiliation | Stevens, Claire H, Neuroscience Research Australia, Faculty of Medicine, UNSW | en_US |
| unsw.relation.originalPublicationAffiliation | Rowe, Dominic, Australian School of Advanced Medicine, Macquarie University, Sydney, Australia | en_US |
| unsw.relation.originalPublicationAffiliation | Morel-Kopp, Marie-Christine, Northern Blood Research Centre, Kolling Institute, The University of Sydney and Department of Haematology and Transfusion Medicine, Royal North Shore Hospital, Sydney, Australia | en_US |
| unsw.relation.originalPublicationAffiliation | Orr, Carolyn, Australian School of Advanced Medicine, Macquarie University, Sydney, Australia | en_US |
| unsw.relation.originalPublicationAffiliation | Ranola, Madelaine, Australian School of Advanced Medicine, Macquarie University, Sydney, Australia | en_US |
| unsw.relation.originalPublicationAffiliation | Ward, Christopher, Northern Blood Research Centre, Kolling Institute, The University of Sydney and Department of Haematology and Transfusion Medicine, Royal North Shore Hospital, Sydney, Australia | en_US |
| unsw.relation.originalPublicationAffiliation | Halliday, Glenda, Neuroscience Research Australia, Faculty of Medicine, UNSW | en_US |
| unsw.relation.originalPublicationAffiliation | Russell, Tonia, The Ramaciotti Centre, Faculty of Science, UNSW | en_US |
| unsw.relation.school | Neuroscience Research Australia | * |
| unsw.subject.fieldofresearchcode | 110903 Central Nervous System | en_US |
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