Reduced T helper and B lymphocytes in Parkinson’s disease

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Abstract
Gene association with HLA suggests involvement of immune mediated mechanisms in the pathogenesis of Parkinson’s disease (PD). Only a small number of studies have found differences between circulating leukocyte populations in PD patients compared to controls, with conflicting results. To clarify whether there is a circulating leukocyte PD phenotype, we assessed the numbers of T, B and natural killer cells, and monocytes and found a small reduction (15-25%) in CD4+ T and CD19+ B cells in PD. These findings suggest some compromise in immune cells in PD and have potential implications for immune function and the progression of PD.
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Author(s)
Stevens, Claire H
Rowe, Dominic
Morel-Kopp, Marie-Christine
Orr, Carolyn
Ranola, Madelaine
Ward, Christopher
Halliday, Glenda
Russell, Tonia
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Publication Year
2012
Resource Type
Journal Article
Degree Type
UNSW Faculty
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