Publication:
The terminals of myenteric intrinsic primary afferent neurons of the guinea-pig ileum are excited by 5-hydroxytryptamine acting at 5-hydroxytryptamine-3 receptors
The terminals of myenteric intrinsic primary afferent neurons of the guinea-pig ileum are excited by 5-hydroxytryptamine acting at 5-hydroxytryptamine-3 receptors
dc.contributor.author | Bertrand, P. P | en_US |
dc.contributor.author | Kunze, W. A. | en_US |
dc.contributor.author | Furness, J. B. | en_US |
dc.contributor.author | Bornstein, J. C. | en_US |
dc.date.accessioned | 2021-11-25T13:35:21Z | |
dc.date.available | 2021-11-25T13:35:21Z | |
dc.date.issued | 2000 | en_US |
dc.description.abstract | The aim of this study was to identify the receptor type(s) by which 5-hydroxytryptamine applied to the intestinal mucosa excites the terminals of myenteric AH neurons. The AH neurons have been identified as the intrinsic primary afferent (sensory) neurons in guinea-pig small intestine and 5-hydroxytryptamine has been identified as a possible intermediate in the sensory transduction process. Intracellular recordings were taken from AH neurons located within 1 mm of intact mucosa to which 5-hydroxytryptamine was applied. Trains of action potentials and/or slow depolarizing responses were recorded in AH neurons in response to mucosal application of 5-hydroxytryptamine (10 or 20 μM) or the 5-hydroxytryptamine-3 receptor agonist, 2-methyl-5-hydroxytryptamine (1 or 3 mM), and to electrical stimulation of the mucosa. The 5-hydroxytryptamine-2 receptor agonist, α-methyl-5-hydroxytryptamine (100 μM), and the 5-hydroxytryptamine-1,2,4 receptor agonist, 5-methoxytryptamine (10 μM), did not elicit such responses. The 5-hydroxytryptamine-3 receptor-selective antagonist, granisetron (typically 1 μM), and the 5-hydroxytryptamine-3,4 receptor antagonist, tropisetron (typically 1 μM), each reduced or abolished the responses to 5-hydroxytryptamine, while the selective 5-hydroxytryptamine-4 receptor antagonist, SB 204070 (1 μM), did not. It is concluded that application of 5-hydroxytryptamine to the mucosa activates a 5-hydroxytryptamine-3 receptor that triggers action potential generation in the mucosal nerve terminals of myenteric AH neurons. | en_US |
dc.identifier.issn | 0306-4522 | en_US |
dc.identifier.uri | http://hdl.handle.net/1959.4/40049 | |
dc.language | English | |
dc.language.iso | EN | en_US |
dc.rights | CC BY-NC-ND 3.0 | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/au/ | en_US |
dc.source | Legacy MARC | en_US |
dc.title | The terminals of myenteric intrinsic primary afferent neurons of the guinea-pig ileum are excited by 5-hydroxytryptamine acting at 5-hydroxytryptamine-3 receptors | en_US |
dc.type | Journal Article | en |
dcterms.accessRights | metadata only access | |
dspace.entity.type | Publication | en_US |
unsw.accessRights.uri | http://purl.org/coar/access_right/c_14cb | |
unsw.identifier.doiPublisher | http://dx.doi.org/10.1016/S0306-4522(00)00363-8 | en_US |
unsw.relation.faculty | Medicine & Health | |
unsw.relation.ispartofjournal | Neuroscience | en_US |
unsw.relation.ispartofpagefrompageto | 459-469 | en_US |
unsw.relation.ispartofvolume | 101 | en_US |
unsw.relation.originalPublicationAffiliation | Bertrand, P. P, Medical Sciences, Faculty of Medicine, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Kunze, W. A. | en_US |
unsw.relation.originalPublicationAffiliation | Furness, J. B. | en_US |
unsw.relation.originalPublicationAffiliation | Bornstein, J. C. | en_US |
unsw.relation.school | School of Medical Sciences | * |