Mechanisms of Alcoholic Pancreatitis Apte, Minoti en_US Pirola, Romano en_US Wilson, Jeremy en_US 2021-11-25T12:28:41Z 2021-11-25T12:28:41Z 2010 en_US
dc.description.abstract Alcoholic pancreatitis is a major complication of alcohol abuse. The risk of developing pancreatitis increases with increasing doses of alcohol, suggesting that alcohol exerts dose-related toxic effects on the pancreas. However, it is also clear that only a minority of alcoholics develop the disease, indicating that an additional trigger may be required to initiate clinically evident pancreatic injury. It is now well established that alcohol is metabolised by the pancreas via both oxidative and non-oxidative metabolites. Alcohol and its metabolites produce changes in the acinar cells which may promote premature intracellular digestive enzyme activation thereby predisposing the gland to autodigestive injury. Pancreatic stellate cells (PSCs) are activated directly by alcohol and its metabolites and also by cytokines and growth factors released during alcohol-induced pancreatic necroinflammation. Activated PSCs are the key cells responsible for producing the fibrosis of alcoholic chronic pancreatitis. Efforts to identify clinically relevant factors that may explain the susceptibility of some alcoholics to pancreatitis have been underway for several years. An unequivocal, functionally characterised, association is yet to be identified in clinical studies, although in the experimental setting, endotoxin has been shown to trigger overt pancreatic injury and to promote disease progression in alcohol-fed animals. Thus, while the molecular effects of alcohol on the pancreas have been increasingly clarified in recent years, identification of predisposing or triggering factors remains a challenge. en_US
dc.identifier.issn 0815-9319 en_US
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.subject.other pancreatic stellate cells en_US
dc.subject.other alcohol en_US
dc.subject.other pancreatitis en_US
dc.title Mechanisms of Alcoholic Pancreatitis en_US
dc.type Journal Article en
dcterms.accessRights open access
dspace.entity.type Publication en_US
unsw.description.publisherStatement This is the accepted version of the article, Mechanisms of Alcoholic Pancreatitis, which has been published in final form at en_US
unsw.identifier.doiPublisher en_US
unsw.relation.FunderRefNo 630509 en_US
unsw.relation.FunderRefNoURL en_US
unsw.relation.faculty Medicine & Health
unsw.relation.fundingScheme NHMRC Project en_US
unsw.relation.ispartofissue 12 en_US
unsw.relation.ispartofjournal Journal of Gastroenterology and Hepatology en_US
unsw.relation.ispartofpagefrompageto 1816-1826 en_US
unsw.relation.ispartofvolume 25 en_US
unsw.relation.originalPublicationAffiliation Apte, Minoti, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Pirola, Romano, Clinical School - South Western Sydney, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Wilson, Jeremy, Clinical School - South Western Sydney, Faculty of Medicine, UNSW en_US Clinical School South West Sydney Area Health Service *
unsw.subject.fieldofresearchcode 110307 Gastroenterology and Hepatology en_US
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