Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects Halliday, Glenda en_US Bigio, Eileen H en_US Cairns, Nigel J en_US Neumann, Manuela en_US Mackenzie, Ian R en_US Mann, David MA en_US 2021-11-25T12:28:45Z 2021-11-25T12:28:45Z 2012 en_US
dc.description.abstract Frontotemporal lobar degeneration (FTLD) is clinically, pathologically and genetically heterogeneous. The prototypical clinical syndromes are behavioural variant frontotemporal dementia (bvFTD), a disorder of behaviour and executive impairments, progressive non-fluent aphasia (PNFA), a disorder of expressive language, and semantic dementia (SD), a disorder of conceptual knowledge [Neary et al 1998]. A proportion of patients with any of these syndromes of FTLD can develop the amyotrophic form of motor neurone disease (MND) [Neary et al 1990, Strong et al], further emphasising clinical heterogeneity within FTLD, and highlighting the long known association with, and suspected pathogenetic links between, FTLD and MND. en_US
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.subject.other progressive non-fluent aphasia en_US
dc.subject.other Frontotemporal lobar degeneration en_US
dc.subject.other behavioural variant en_US
dc.subject.other semantic dementia en_US
dc.title Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects en_US
dc.type Journal Article en
dcterms.accessRights open access
dspace.entity.type Publication en_US
unsw.description.publisherStatement The final publication is available at Springer via en_US
unsw.identifier.doiPublisher en_US
unsw.relation.FunderRefNo GNT0630434 en_US
unsw.relation.faculty Medicine & Health
unsw.relation.fundingScheme Uncoupled Research Fellowship en_US
unsw.relation.ispartofissue 3 en_US
unsw.relation.ispartofjournal Acta Neuropathologica en_US
unsw.relation.ispartofpagefrompageto 373-382 en_US
unsw.relation.ispartofvolume 124 en_US
unsw.relation.originalPublicationAffiliation Halliday, Glenda, Neuroscience Research Australia, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Bigio, Eileen H, 2Department of Pathology and Alzheimer Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA en_US
unsw.relation.originalPublicationAffiliation Cairns, Nigel J, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA en_US
unsw.relation.originalPublicationAffiliation Neumann, Manuela, Department of Neuropathology, University of Tuebingen and German Center for Neurodegenerative Diseases Tuebingen, Tuebingen, Germany en_US
unsw.relation.originalPublicationAffiliation Mackenzie, Ian R, Department of Pathology, University of British Columbia, Vancouver, Canada en_US
unsw.relation.originalPublicationAffiliation Mann, David MA, School of Community Based Medicine, University of Manchester, Manchester, UK en_US Neuroscience Research Australia *
unsw.subject.fieldofresearchcode 110903 Central Nervous System en_US
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