Purinergic receptors and synaptic transmission in enteric neurons Ren, J en_US Bertrand, Paul en_US 2021-11-25T13:36:06Z 2021-11-25T13:36:06Z 2008 en_US
dc.description.abstract Purines such as ATP and adenosine participate in synaptic transmission in the enteric nervous system as neurotransmitters or neuromodulators. Purinergic receptors are localized on the cell bodies or nerve terminals of different functional classes of enteric neurons and, with other receptors, form unique receptor complements. Activation of purinergic receptors can regulate neuronal activity by depolarization, by regulating intracellular calcium, or by modulating second messenger pathways. Purinergic signaling between enteric neurons plays an important role in regulating specific enteric reflexes and overall gastrointestinal function. In the present article, we review evidence for purine receptors in the enteric nervous system, including P1 (adenosine) receptors and P2 (ATP) receptors. We will explore the role they play in mediating fast and slow synaptic transmission and in presynaptic inhibition of transmission. Finally, we will examine the molecular properties of the native receptors, their signaling mechanisms, and their role in gastrointestinal pathology. en_US
dc.identifier.issn 1573-9538 en_US
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.subject.other synaptic transmission en_US
dc.subject.other adenosine receptors en_US
dc.subject.other enteric nervous system en_US
dc.subject.other gastrointestinal tract en_US
dc.subject.other P2X receptors en_US
dc.subject.other P2Y receptors en_US
dc.subject.other purines en_US
dc.subject.other synaptic transmission en_US
dc.title Purinergic receptors and synaptic transmission in enteric neurons en_US
dc.type Journal Article en
dcterms.accessRights open access
dspace.entity.type Publication en_US
unsw.description.publisherStatement The original publication is available at en_US
unsw.identifier.doiPublisher en_US
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofissue 3 en_US
unsw.relation.ispartofjournal Purinergic Signalling en_US
unsw.relation.ispartofpagefrompageto 255-266 en_US
unsw.relation.ispartofvolume 4 en_US
unsw.relation.originalPublicationAffiliation Ren, J en_US
unsw.relation.originalPublicationAffiliation Bertrand, Paul, Medical Sciences, Faculty of Medicine, UNSW en_US School of Medical Sciences *
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