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Extending the dynamic range of electrochemical sensors using multiple modified electrodes

dc.contributor.author Chow, Edith en_US
dc.contributor.author Wong, Elicia en_US
dc.contributor.author Pascoe, O en_US
dc.contributor.author Hibbert, D. Brynn en_US
dc.contributor.author Gooding, John en_US
dc.date.accessioned 2021-11-25T13:02:10Z
dc.date.available 2021-11-25T13:02:10Z
dc.date.issued 2007 en_US
dc.description.abstract Multiple electrodes, combined with a chemometric strategy to calibrate the measurement response, have been used for the determination of an analyte across a broader dynamic range than is possible with a single electrode. The model system used for the detection of copper comprised electrodes modified with a self-assembled monolayer. The electrodes were modified with the copper-complexing species (3-mercaptopropionic acid, thioctic acid, and the peptides cysteine and Gly-Gly-His) and copper was determined over concentrations ranging from nanomolar to millimolar using voltammetric analysis. We have demonstrated that by combining the calibration functions from the four electrodes a better estimate (i.e. with smaller variance) of the concentration of the analyte is obtained. Measurement uncertainty is expressed for independently prepared electrodes, which allows the possibility of commercial production and factory calibration. The principles of using multiple electrodes modified with recognition elements with different affinities for the target analyte to extend the dynamic range of sensors is a general one that could be applied to other analytes. © Springer-Verlag 2007. en_US
dc.identifier.issn 1618-2642 en_US
dc.identifier.uri http://hdl.handle.net/1959.4/38987
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/3.0/au/ en_US
dc.source Legacy MARC en_US
dc.subject.other Electrochemical sensors en_US
dc.subject.other Amino acids en_US
dc.subject.other Biosensors en_US
dc.subject.other Copper en_US
dc.subject.other Electrochemical electrodes en_US
dc.subject.other Monolayers en_US
dc.title Extending the dynamic range of electrochemical sensors using multiple modified electrodes en_US
dc.type Journal Article en
dcterms.accessRights open access
dspace.entity.type Publication en_US
unsw.accessRights.uri https://purl.org/coar/access_right/c_abf2
unsw.description.publisherStatement The original publication is available at www.springerlink.com en_US
unsw.identifier.doiPublisher http://dx.doi.org/10.1007/s00216-006-1022-0 en_US
unsw.relation.faculty Science
unsw.relation.ispartofissue 4 en_US
unsw.relation.ispartofjournal Analytical and Bioanalytical Chemistry en_US
unsw.relation.ispartofpagefrompageto 1489-1498 en_US
unsw.relation.ispartofvolume 387 en_US
unsw.relation.originalPublicationAffiliation Chow, Edith, Chemistry, Faculty of Science, UNSW en_US
unsw.relation.originalPublicationAffiliation Wong, Elicia, Chemistry, Faculty of Science, UNSW en_US
unsw.relation.originalPublicationAffiliation Pascoe, O, Chemistry, Faculty of Science, UNSW en_US
unsw.relation.originalPublicationAffiliation Hibbert, D. Brynn, Chemistry, Faculty of Science, UNSW en_US
unsw.relation.originalPublicationAffiliation Gooding, John, Chemistry, Faculty of Science, UNSW en_US
unsw.relation.school School of Chemistry *
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