Aspects of innate immunity and Parkinson’s disease Huang, Yue en_US Halliday, Glenda en_US 2021-11-25T12:29:30Z 2021-11-25T12:29:30Z 2012 en_US
dc.description.abstract Genetic studies on PARK genes have identified dysfunction in proteasomal, lysosomal, and mitochondrial enzymes as pathogenic for Parkinson’s disease(PD). We review the role of these and similar enzymes in mediating innate immunesignaling. In particular, we have identified that a number of PARK gene products as well as other enzymes have roles in innate immunesignaling as well as DNA repair and regulation biquitination, mitochondrial functioning, and synaptic trafficking. PD enzymatic dysfunction is likely to contribute to inadequate innate immune responses to a variety of extra-and intracellular stimuli, with a number of the innate immunity related enzymes found in the characteristic Lewy body pathology of PD. The decrease in innate immunity in PD is associated with an increase in markers of adaptive immunity, and recent GWAS studies have identified variants in human leukocyte antigen region asassociated with late-onset sporadicPD(Hamzaetal.,2010;Hill-Burnsetal.,2011). Intriguing newdata also suggest that peripheral immune responses maybe involved, giving some potential to alleviate such peripheral dysfunction more directly in patients with PD. It is now important to identify the cell type specific immune responses contributing to the initial changes that occur in PD, as well as to the propagating immune responses important for the progression of PD pathology between cells and within the brain. Overall, a complex interplay between different types of immunity appear to be involved in the underlying pathology of PD. en_US
dc.identifier.issn 1663-9812 en_US
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.subject.other Parkinson’s disease en_US
dc.subject.other immunity en_US
dc.subject.other mitochondrial dysfunction en_US
dc.subject.other synapse dysfunction en_US
dc.subject.other ubiquitination en_US
dc.title Aspects of innate immunity and Parkinson’s disease en_US
dc.type Journal Article en
dcterms.accessRights open access
dspace.entity.type Publication en_US
unsw.description.publisherStatement This document is protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission. en_US
unsw.identifier.doiPublisher en_US
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofissue 33 en_US
unsw.relation.ispartofjournal Frontiers in Pharmacology en_US
unsw.relation.ispartofpagefrompageto 1-10 en_US
unsw.relation.ispartofvolume 3 en_US
unsw.relation.originalPublicationAffiliation Huang, Yue, Neuroscience Research Australia, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Halliday, Glenda, Neuroscience Research Australia, Faculty of Medicine, UNSW en_US Neuroscience Research Australia *
unsw.subject.fieldofresearchcode 110903 Central Nervous System en_US
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