Publication:
Screening and Preventive Behaviors one year after predictive genetic testing for hereditary nonpolyposis colorectal carcinoma

dc.contributor.author Collins, Veronica en_US
dc.contributor.author Meiser, Bettina en_US
dc.contributor.author Gaff, Clara en_US
dc.contributor.author St. John, D en_US
dc.contributor.author Halliday, Jane en_US
dc.date.accessioned 2021-11-25T13:01:49Z
dc.date.available 2021-11-25T13:01:49Z
dc.date.issued 2005 en_US
dc.description.abstract Background: Prevention benefits from predictive genetic testing for cancer will only be fully realized if appropriate screening is adopted after testing. The current study assessed screening and preventive behaviors during 12 months after predictive genetic testing for hereditary nonpolyposis colorectal carcinoma (HNPCC) in an Australian clinical cohort. Methods: Participants received predictive genetic testing for HNPCC at one of five Australian familial cancer clinics. Data on self-reported screening behaviors (colonoscopy, and endometrial sampling and transvaginal ultrasound for women) and prophylactic surgery (colectomy, and hysterectomy and bilateral oophorectomy for women) were collected using postal questionnaires before (baseline) and 12 months after receipt of genetic test results. Age, gender, perceived risk of cancer, and cancer-specific distress were assessed as predictors of colonoscopic screening. Results: In the current study, 114 participants returned baseline questionnaires (32 carriers and 82 noncarriers of an HNPCC mutation). Ninety-eight participants also returned a 12-month follow-up questionnaire. Of those 25 years, 73% reported having had a colonoscopy before genetic testing. At follow-up, 71% (15 of 25) of carriers and 12% (8 of 65) of noncarriers reported having a colonoscopy in the 12 months after receipt of test results. The reduction in colonoscopy among noncarriers was statistically significant (P < 0.001). High perceived risk was associated with colonoscopy at baseline. At follow-up, mutation status was the only variable significantly associated with colonoscopy. Among female mutation carriers, 47% reported having transvaginal ultrasonography and 53% endometrial sampling during follow-up. There was low uptake of prophylactic surgery for colorectal, endometrial, or ovarian carcinomas. Conclusions: The majority of individuals reported appropriate screening behaviors after predictive genetic testing for HNPCC. The small group of noncarriers who had screening after genetic testing might benefit from additional counseling. Cancer 2005. © 2005 American Cancer Society. en_US
dc.identifier.uri http://hdl.handle.net/1959.4/38973
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/3.0/au/ en_US
dc.source Legacy MARC en_US
dc.title Screening and Preventive Behaviors one year after predictive genetic testing for hereditary nonpolyposis colorectal carcinoma en_US
dc.type Journal Article en
dcterms.accessRights metadata only access
dspace.entity.type Publication en_US
unsw.accessRights.uri http://purl.org/coar/access_right/c_14cb
unsw.identifier.doiPublisher http://dx.doi.org/10.1002/cncr.21183 en_US
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofissue 2 en_US
unsw.relation.ispartofjournal Cancer en_US
unsw.relation.ispartofpagefrompageto 273-278 en_US
unsw.relation.ispartofvolume 104 en_US
unsw.relation.originalPublicationAffiliation Collins, Veronica, Public Health Genetics, Murdoch Childrens Research Institute en_US
unsw.relation.originalPublicationAffiliation Meiser, Bettina, Prince of Wales Clinical School, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Gaff, Clara, Genetic Health Services Victoria, Royal Children's Hospital en_US
unsw.relation.originalPublicationAffiliation St. John, D, Familial Cancer Centre, The Royal Melbourne Hospital en_US
unsw.relation.originalPublicationAffiliation Halliday, Jane, Public Health Genetics, Murdoch Childrens Research Institute en_US
unsw.relation.school Clinical School Prince of Wales Hospital *
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