Publication:
Psychological impact of genetic testing for hereditary non-polyposis colorectal cancer
Psychological impact of genetic testing for hereditary non-polyposis colorectal cancer
dc.contributor.author | Meiser, Bettina | en_US |
dc.contributor.author | Collins, V | en_US |
dc.contributor.author | Warren, R | en_US |
dc.contributor.author | Gaff, C | en_US |
dc.contributor.author | St John, D | en_US |
dc.contributor.author | Young, M | en_US |
dc.contributor.author | Harrop, K | en_US |
dc.contributor.author | Brown, Julieanne | en_US |
dc.contributor.author | Halliday, J | en_US |
dc.date.accessioned | 2021-11-25T13:07:43Z | |
dc.date.available | 2021-11-25T13:07:43Z | |
dc.date.issued | 2004 | en_US |
dc.description.abstract | The psychological impact of predictive genetic testing for hereditary non-polyposis colorectal cancer (HNPCC) was assessed in 114 individuals (32 carriers and 82 non-carriers) attending familial cancer clinics, using mailed self-administered questionnaires prior to, 2 weeks, 4 months and 12 months after carrier status disclosure. Compared to baseline, carriers showed a significant increase in mean scores for intrusive and avoidant thoughts about colorectal cancer 2 weeks (t = 2.49; p = 0.014) and a significant decrease in mean depression scores 2 weeks post-notification of result (t = -3.98; p < 0.001) and 4 months post-notification of result (t = -3.22; p = 0.002). For non-carriers, significant decreases in mean scores for intrusive and avoidant thoughts about colorectal cancer were observed at all follow-up assessment time points relative to baseline. Non-carriers also showed significant decreases from baseline in mean depression scores 2 weeks, 4 months and 12 months post-notification. Significant decreases from baseline for mean state anxiety scores were also observed for non-carriers 2 weeks post-notification (t = -3.99; p < 0.001). These data indicate that predictive genetic testing for HNPCC leads to psychological benefits amongst non-carriers, and no adverse psychological outcomes were observed amongst carriers. | en_US |
dc.identifier.issn | 0009-9163 | en_US |
dc.identifier.uri | http://hdl.handle.net/1959.4/39202 | |
dc.language | English | |
dc.language.iso | EN | en_US |
dc.rights | CC BY-NC-ND 3.0 | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/au/ | en_US |
dc.source | Legacy MARC | en_US |
dc.title | Psychological impact of genetic testing for hereditary non-polyposis colorectal cancer | en_US |
dc.type | Journal Article | en |
dcterms.accessRights | open access | |
dspace.entity.type | Publication | en_US |
unsw.accessRights.uri | https://purl.org/coar/access_right/c_abf2 | |
unsw.description.publisherStatement | The definitive version is available at www.blackwell-synergy.com | en_US |
unsw.identifier.doiPublisher | http://dx.doi.org/10.1111/j.1399-0004.2004.00339.x | en_US |
unsw.relation.faculty | Medicine & Health | |
unsw.relation.ispartofissue | 6 | en_US |
unsw.relation.ispartofjournal | Clinical Genetics | en_US |
unsw.relation.ispartofpagefrompageto | 502-511 | en_US |
unsw.relation.ispartofvolume | 66 | en_US |
unsw.relation.originalPublicationAffiliation | Meiser, Bettina, Prince of Wales Clinical School, Faculty of Medicine, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Collins, V | en_US |
unsw.relation.originalPublicationAffiliation | Warren, R | en_US |
unsw.relation.originalPublicationAffiliation | Gaff, C | en_US |
unsw.relation.originalPublicationAffiliation | St John, D | en_US |
unsw.relation.originalPublicationAffiliation | Young, M | en_US |
unsw.relation.originalPublicationAffiliation | Harrop, K | en_US |
unsw.relation.originalPublicationAffiliation | Brown, Julieanne, Prince of Wales Clinical School, Faculty of Medicine, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Halliday, J | en_US |
unsw.relation.school | Clinical School Prince of Wales Hospital | * |
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