Glucocerebrosidase deficits in sporadic Parkinson disease Murphy, Karen E en_US Halliday, Glenda en_US 2021-11-25T12:29:05Z 2021-11-25T12:29:05Z 2014 en_US
dc.description.abstract Parkinson disease (PD) is a progressive neurodegenerative movement disorder characterized pathologically by abnormal SNCA/α-synuclein protein inclusions in neurons. Impaired lysosomal autophagic degradation of cellular proteins is implicated in PD pathogenesis and progression. Heterozygous GBA mutations, encoding lysosomal GBA/glucocerebrosidase (glucosidase, beta, acid), are the greatest genetic risk factor for PD, and reduced GBA and SNCA accumulation are related in PD models. Here we review our recent human brain tissue study demonstrating that GBA deficits in sporadic PD are related to the early accumulation of SNCA, and dysregulation of chaperone-mediated autophagy (CMA) pathways and lipid metabolism. en_US
dc.identifier.issn 1554-8627 en_US
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.subject.other ceramide en_US
dc.subject.other Parkinson disease en_US
dc.subject.other α-synuclein en_US
dc.subject.other glucocerebrosidase en_US
dc.subject.other lysosomes en_US
dc.subject.other chaperonemediated autophagy en_US
dc.subject.other autophagy en_US
dc.title Glucocerebrosidase deficits in sporadic Parkinson disease en_US
dc.type Journal Article en
dcterms.accessRights open access
dspace.entity.type Publication en_US
unsw.identifier.doiPublisher en_US
unsw.relation.FunderRefNo GNT1008307 en_US
unsw.relation.FunderRefNoURL en_US
unsw.relation.faculty Medicine & Health
unsw.relation.fundingScheme NHMRC Project en_US
unsw.relation.ispartofissue 7 en_US
unsw.relation.ispartofjournal Autophagy en_US
unsw.relation.ispartofpagefrompageto 1350-1351 en_US
unsw.relation.ispartofvolume 10 en_US
unsw.relation.originalPublicationAffiliation Murphy, Karen E, Neuroscience Research Australia, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Halliday, Glenda, Neuroscience Research Australia, Faculty of Medicine, UNSW en_US Neuroscience Research Australia *
unsw.subject.fieldofresearchcode 110903 Central Nervous System en_US
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Final draft post-referrering.pdf
97.07 KB
Resource type