Experimental basis for realistic large scale computer simulation of the enteric nervous system Furness, J. B. en_US Bornstein, J. C. en_US Kunze, W. A. en_US Bertrand, P. P en_US Kelly, H. en_US Thomas, E. A. en_US 2021-11-25T13:35:00Z 2021-11-25T13:35:00Z 1996 en_US
dc.description.abstract 1. The enteric nervous system is perhaps the most accessible part of the mammalian nervous system in which it is feasible to attempt large scale computer simulation that is based closely on experimentally determined data. Here we summarize the data obtained for simulation of motility reflexes in the guinea-pig small intestine. 2. The chemistry, morphology and connectivity of each type of neuron involved in intrinsic reflexes have been investigated and most classes of neurons are physiologically well characterized. This includes primary sensory neurons, ascending and descending interneurons and motor neurons to circular and longitudinal muscle. 3. The responses of primary sensory neurons and the physiology of synaptic transmission from sensory neurons to interneurons and motor neurons, from interneurons to interneurons and from interneurons to motor neurons have been recorded during reflexes and in some cases the pharmacology of transmission has also been investigated. 4. Computer simulation, in which the activities of up to 30,000 neurons are modelled, produces patterns of activity that closely mimic those recorded in physiological experiments. en_US
dc.identifier.issn 0305-1870 en_US
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.title Experimental basis for realistic large scale computer simulation of the enteric nervous system en_US
dc.type Journal Article en
dcterms.accessRights metadata only access
dspace.entity.type Publication en_US
unsw.identifier.doiPublisher en_US
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofissue 9 en_US
unsw.relation.ispartofjournal Clinical and Experimental Pharmacology and Physiology en_US
unsw.relation.ispartofpagefrompageto 786-792 en_US
unsw.relation.ispartofvolume 23 en_US
unsw.relation.originalPublicationAffiliation Furness, J. B. en_US
unsw.relation.originalPublicationAffiliation Bornstein, J. C. en_US
unsw.relation.originalPublicationAffiliation Kunze, W. A. en_US
unsw.relation.originalPublicationAffiliation Bertrand, P. P, Medical Sciences, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Kelly, H. en_US
unsw.relation.originalPublicationAffiliation Thomas, E. A. en_US School of Medical Sciences *
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