An emerging role for LRRK2 in the immune system Dzamko, Nicolas en_US Halliday, Glenda en_US 2021-11-25T12:28:40Z 2021-11-25T12:28:40Z 2012 en_US
dc.description.abstract Missense mutations in leucine-rich repeat kinase 2 (LRRK2) contribute significantly to autosomal dominant Parkinson’s disease (PD). Genome-wide association studies have further suggested that mutations in LRRK2 comprise a risk factor for sporadic PD. How LRRK2 contributes to PD however, is largely unknown. Recent work has shown that LRRK2 is highly expressed in tissue and circulating immune cells and is suggestive of a potential role for LRRK2 in innate immunity. These studies and their potential implications for PD will be discussed. en_US
dc.identifier.issn 0300-5127 en_US
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.subject.other innate immunity en_US
dc.subject.other leucine-rich repeat kinase 2 en_US
dc.subject.other Parkinson’s disease en_US
dc.title An emerging role for LRRK2 in the immune system en_US
dc.type Journal Article en
dcterms.accessRights open access
dspace.entity.type Publication en_US
unsw.description.publisherStatement The final version of record is available at Biochemical Society Transactions website: en_US
unsw.identifier.doiPublisher en_US
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofissue 5 en_US
unsw.relation.ispartofjournal Biochemical Society Transactions en_US
unsw.relation.ispartofpagefrompageto 1134-1139 en_US
unsw.relation.ispartofvolume 40 en_US
unsw.relation.originalPublicationAffiliation Dzamko, Nicolas, Neuroscience Research Australia, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Halliday, Glenda, Neuroscience Research Australia, Faculty of Medicine, UNSW en_US Neuroscience Research Australia *
unsw.subject.fieldofresearchcode 110903 Central Nervous System en_US
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