Perinatal and maternal risk factors for autism spectrum disorders in NSW Williams, Katrina en_US Helmer, M. en_US Duncan, G. W. en_US Peat, J. K. en_US Mellis, CM en_US 2021-11-25T12:46:06Z 2021-11-25T12:46:06Z 2008 en_US
dc.description.abstract Background This study was commenced in 1999 with the aim of examining risk factors for autism using established population-based data for comparison.Methods Cases were ascertained using active surveillance and compared with birth data.Results Four risk factors were found to be significantly associated with autism using binary logistic regression analysis; being male [adjusted odds ratio (OR) 4.7, 95% confidence interval (CI) 3.2–7.0], being born prematurely (adjusted OR 2.2, 95% CI 1.5–3.5), having maternal age ≥35 years (adjusted OR 1.7, 95% CI 1.2–2.4) and having a mother born outside Australia (adjusted OR 1.4, 95% CI 1.0–1.9). For analysis completed for pregnancies, rather than live births, multiple birth was also a significant risk factor for one or more children of the pregnancy to be affected by autism (adjusted OR 2.5, 95% CI 1.1–5.5). There was a statistically significant trend towards increasing risk with increasing risk factor 'dose' for gestational age (P = 0.019), multiple birth (P = 0.016) and maternal age (P < 0.001). For mother's country of birth the group with the highest risk were children of mother's born in south-east or north-east Asia. There was a non-significant trend towards a higher proportion of children with developmental disability having risk factors.Conclusion Replication of risk factors from previous studies and a significant risk factor 'dose' effect add to growing evidence that maternal and perinatal factors are low magnitude risk factors for autism. The association between developmental disability and autism risk factors warrants further examination. en_US
dc.identifier.issn 1365-2214 en_US
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.subject.other autism en_US
dc.subject.other maternal en_US
dc.subject.other perinatal en_US
dc.subject.other risk factors en_US
dc.title Perinatal and maternal risk factors for autism spectrum disorders in NSW en_US
dc.type Journal Article en
dcterms.accessRights metadata only access
dspace.entity.type Publication en_US
unsw.identifier.doiPublisher en_US
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofissue 2 en_US
unsw.relation.ispartofjournal Child: Care, Health and Development en_US
unsw.relation.ispartofpagefrompageto 249-256 en_US
unsw.relation.ispartofvolume 34 en_US
unsw.relation.originalPublicationAffiliation Williams, Katrina, Women's & Children's Health, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Helmer, M. en_US
unsw.relation.originalPublicationAffiliation Duncan, G. W. en_US
unsw.relation.originalPublicationAffiliation Peat, J. K. en_US
unsw.relation.originalPublicationAffiliation Mellis, CM en_US School of Women's & Children's Health *
Resource type