Motor deficits that associate with changes in β-amyloid in Parkinson’s disease

Abstract

β-Amyloid (Aβ) deposition in the brain is one of the main pathologic hallmarks of Alzheimer’s disease (AD) with dominant gene mutations significantly increasing the amount of this protein in the brain and heralding an early onset of dementia 1. Deposition of Aβ in the brain identified by PET imaging is closely associated with decreased CSF levels of the protein, tools that are now used clinically to assist with the diagnosis of AD.