Whisker maps in marsupials: Nerve lesions and critical periods Waite, Phil en_US Gorrie, Catherine en_US Herath, N en_US Marotte, Lauren en_US 2021-11-25T12:54:13Z 2021-11-25T12:54:13Z 2006 en_US
dc.description.abstract In the wallaby, whisker-related patterns develop over a protracted period of postnatal maturation in the pouch. Afferents arrive simultaneously in the thalamus and cortex from postnatal day (P) 15. Whisker-related patterns are first seen in the thalamus at P50 and are well formed by P73, before cortical patterns first appear (P75) or are well developed (P85). This study used the slow developmental sequence and accessibility of the pouch young to investigate the effect of nerve lesions before afferent arrival, or at times when thalamic patterns are obvious but cortical patterns not yet formed. The left infraorbital nerve supplying the whiskers was cut at P0-93 and animals were perfused at P112-123. Sections through the thalamus (horizontal plane) and cortex (tangential) were reacted for cytochrome oxidase to visualize whisker-related patterns. Lesions of the nerve at P2-5, before innervation of the thalamus or cortex, resulted in an absence of patterns at both levels. Lesions from P66-77 also disrupted thalamic and cortical patterns, despite the fact that thalamic patterns are normally well established by P73. Lesions from P82-93 resulted in normal thalamic and cortical patterns. Thus, despite the wallaby having clearly separated times for the development of patterns at different levels of the pathway, these results suggest a single critical period for the thalamus and cortex, coincident with the maturation of the cortical pattern. Possible mechanisms underpinning this critical period could include dependence of the thalamic pattern on corticothalamic activity or peripheral signals to allow consolidation of thalamic barreloids. (c) 2006 Wiley-Liss, Inc. en_US
dc.identifier.issn 1552-4884 en_US
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.subject.other trigeminal pathway en_US
dc.subject.other vibrissa en_US
dc.subject.other barrel en_US
dc.subject.other somatosensory development en_US
dc.subject.other whisker follicles en_US
dc.title Whisker maps in marsupials: Nerve lesions and critical periods en_US
dc.type Journal Article en
dcterms.accessRights metadata only access
dspace.entity.type Publication en_US
unsw.identifier.doiPublisher en_US
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofissue 2 en_US
unsw.relation.ispartofjournal Anatomical record Part A - Discoveries in molecular cellular and evolutionary biology en_US
unsw.relation.ispartofpagefrompageto 174-181 en_US
unsw.relation.ispartofvolume 288A en_US
unsw.relation.originalPublicationAffiliation Waite, Phil, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Gorrie, Catherine, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Herath, N en_US
unsw.relation.originalPublicationAffiliation Marotte, Lauren en_US
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