Evidence for positive selection on Mycobacterium tuberculosis within patients Tanaka, Mark en_US 2021-11-25T13:26:35Z 2021-11-25T13:26:35Z 2004 en_US
dc.description.abstract BACKGROUND: While the pathogenesis and epidemiology of tuberculosis are well studied, relatively little is known about the evolution of the infectious agent Mycobacterium tuberculosis, especially at the within-host level. The insertion sequence IS6110 is a genetic marker that is widely used to track the transmission of tuberculosis between individuals. This and other markers may also facilitate our understanding of the disease within patients. RESULTS: This article presents three lines of evidence supporting the action of positive selection on M. tuberculosis within patients. The arguments are based on a comparison between empirical findings from molecular epidemiology, and population genetic models of evolution. Under the hypothesis of neutrality of genotypes, 1) the mutation rate of the marker IS6110 is unusually high, 2) the time it takes for substitutions to occur within patients is too short, and 3) the amount of polymorphism within patients is too low. CONCLUSIONS: Empirical observations are explained by the action of positive selection during infection, or alternatively by very low effective population sizes. I discuss the possible roles of antibiotic treatment, the host immune system and extrapulmonary dissemination in creating opportunities for positive selection. en_US
dc.identifier.issn 1471-2148 en_US
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.title Evidence for positive selection on Mycobacterium tuberculosis within patients en_US
dc.type Journal Article en
dcterms.accessRights metadata only access
dspace.entity.type Publication en_US
unsw.identifier.doiPublisher en_US
unsw.relation.faculty Science
unsw.relation.ispartofissue 1 en_US
unsw.relation.ispartofjournal BMC Evolutionary Biology en_US
unsw.relation.ispartofpagefrompageto 31 en_US
unsw.relation.ispartofvolume 4 en_US
unsw.relation.originalPublicationAffiliation Tanaka, Mark, Biotechnology & Biomolecular Sciences, Faculty of Science, UNSW en_US School of Biotechnology & Biomolecular Sciences *
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