Children in reviews: Methodological issues in child-relevant evidence synthesis Cramer, Kristie en_US Wiebe, Natasha en_US Moyer, Virginia en_US Hartling, Lisa en_US Williams, Katrina en_US Swingler, George en_US Klassen, Terry en_US 2021-11-25T12:46:16Z 2021-11-25T12:46:16Z 2005 en_US
dc.description.abstract Background: The delivery of optimal medical care to children is dependent on the availability of child relevant research. Our objectives were to: i) systematically review and describe how children are handled in reviews of drug interventions published in the Cochrane Database of Systematic Reviews (CDSR); and ii) determine when effect sizes for the same drug interventions differ between children and adults. Methods: We systematically identified all of the reviews relevant to child health in the CDSR 2002, Issue 4. Reviews were included if they investigated the efficacy or effectiveness of a drug intervention for a condition that occurs in both children and adults. Information was extracted on review characteristics including study methods, results, and conclusions. Results: From 1496 systematic reviews, 408 (27%) were identified as relevant to both adult and child health; 52% (213) of these included data from children. No significant differences were found in effect sizes between adults and children for any of the drug interventions or conditions investigated. However, all of the comparisons lacked the power to detect a clinically significant difference and wide confidence intervals suggest important differences cannot be excluded. A large amount of data was unavailable due to inadequate reporting at the trial and systematic review level. Conclusion: Overall, the findings of this study indicate there is a paucity of child-relevant and specific evidence generated from evidence syntheses of drug interventions. The results indicate a need for a higher standard of reporting for participant populations in studies of drug interventions. en_US
dc.identifier.issn 1471-2431 en_US
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.title Children in reviews: Methodological issues in child-relevant evidence synthesis en_US
dc.type Journal Article en
dcterms.accessRights metadata only access
dspace.entity.type Publication en_US
unsw.identifier.doiPublisher en_US
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofjournal BMC Pediatrics en_US
unsw.relation.ispartofpagefrompageto 38 en_US
unsw.relation.ispartofvolume 5 en_US
unsw.relation.originalPublicationAffiliation Cramer, Kristie en_US
unsw.relation.originalPublicationAffiliation Wiebe, Natasha en_US
unsw.relation.originalPublicationAffiliation Moyer, Virginia en_US
unsw.relation.originalPublicationAffiliation Hartling, Lisa en_US
unsw.relation.originalPublicationAffiliation Williams, Katrina, Women's & Children's Health, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Swingler, George en_US
unsw.relation.originalPublicationAffiliation Klassen, Terry en_US School of Women's & Children's Health *
Resource type