Publication:
Norovirus recombination in ORF1/ORF2 overlap
Norovirus recombination in ORF1/ORF2 overlap
dc.contributor.author | Bull, Rowena | en_US |
dc.contributor.author | Hansman, Grant | en_US |
dc.contributor.author | Clancy, Leighton | en_US |
dc.contributor.author | Tanaka, Mark | en_US |
dc.contributor.author | Rawlinson, William | en_US |
dc.contributor.author | White, Peter | en_US |
dc.date.accessioned | 2021-11-25T13:26:30Z | |
dc.date.available | 2021-11-25T13:26:30Z | |
dc.date.issued | 2005 | en_US |
dc.description.abstract | Norovirus (NoV) genogroups I and II (GI and GII) are now recognized as the predominant worldwide cause of outbreaks of acute gastroenteritis in humans. Three recombinant NoV GII isolates were identified and characterized, 2 of which are unrelated to any previously published recombinant NoV. Using data from the current study, published sequences, database searches, and molecular techniques, we identified 23 recombinant NoV GII and 1 recombinant NoV GI isolates. Analysis of the genetic relationships among the recombinant NoV GII isolates identified 9 independent recombinant sequences; the other 14 strains were close relatives. Two of the 9 independent recombinant NoV were closely related to other recombinants only in the polymerase region, and in a similar fashion 1 recombinant NoV was closely related to another only in the capsid region. Breakpoint analysis of recombinant NoV showed that recombination occurred in the open reading frame (ORF)1/ORF2 overlap. We provide evidence to support the theory of the role of subgenomic RNA promoters as recombination hotspots and describe a simple mechanism of how recombination might occur in NoV. | en_US |
dc.description.uri | http://www.cdc.gov/ncidod/EID/vol11no07/04-1273.htm | en_US |
dc.identifier.issn | 1080-6040 | en_US |
dc.identifier.uri | http://hdl.handle.net/1959.4/39638 | |
dc.language | English | |
dc.language.iso | EN | en_US |
dc.rights | CC BY-NC-ND 3.0 | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/au/ | en_US |
dc.source | Legacy MARC | en_US |
dc.title | Norovirus recombination in ORF1/ORF2 overlap | en_US |
dc.type | Journal Article | en |
dcterms.accessRights | metadata only access | |
dspace.entity.type | Publication | en_US |
unsw.accessRights.uri | http://purl.org/coar/access_right/c_14cb | |
unsw.relation.faculty | Science | |
unsw.relation.faculty | Medicine & Health | |
unsw.relation.ispartofissue | 7 | en_US |
unsw.relation.ispartofjournal | Emerging Infectious Diseases | en_US |
unsw.relation.ispartofpagefrompageto | 1079-1085 | en_US |
unsw.relation.ispartofvolume | 11 | en_US |
unsw.relation.originalPublicationAffiliation | Bull, Rowena, Biotechnology & Biomolecular Sciences, Faculty of Science, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Hansman, Grant | en_US |
unsw.relation.originalPublicationAffiliation | Clancy, Leighton, Biotechnology & Biomolecular Sciences, Faculty of Science, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Tanaka, Mark, Biotechnology & Biomolecular Sciences, Faculty of Science, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Rawlinson, William, Medical Sciences, Faculty of Medicine, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | White, Peter, Biotechnology & Biomolecular Sciences, Faculty of Science, UNSW | en_US |
unsw.relation.school | School of Biotechnology & Biomolecular Sciences | * |
unsw.relation.school | School of Medical Sciences | * |