Publication:
An action of erythromycin in the intestine that is not mediated via motilin receptors
An action of erythromycin in the intestine that is not mediated via motilin receptors
dc.contributor.author | Furness, J. B. | en_US |
dc.contributor.author | Clark, M. J. | en_US |
dc.contributor.author | Wright, T. | en_US |
dc.contributor.author | Bertrand, P. P | en_US |
dc.contributor.author | Bornstein, J. C. | en_US |
dc.contributor.author | Verlinden, M. | en_US |
dc.date.accessioned | 2021-11-25T13:35:36Z | |
dc.date.available | 2021-11-25T13:35:36Z | |
dc.date.issued | 1999 | en_US |
dc.description.abstract | 1. Erythromycin lactobionate caused a concentration-dependent inhibition of nerve-mediated contractions of the longitudinal muscle of the guinea-pig ileum, with a threshold for effect of 10-30 mumol/L. The non-antibiotic derivative of erythromycin ABT-229 had a similar effect, but was approximately 10-fold less potent. At a greater concentration (1 mmol/L), erythromycin also depressed the direct contractile effect of 10 mumol/L carbachol on the muscle. 2. Human/porcine motilin (up to 100 mumol/L) did not reduce the nerve-mediated contractions, although it did contract the muscle (threshold 30 mumol/L). Antagonists of motilin receptors (phe3leu13motilin, up to 1 mumol/L, and GM-109, up to 3 mumol/L) did not reduce responses to erythromycin. 3. Erythromycin contracted the longitudinal muscle of the rabbit duodenum, with a threshold concentration of 0.1 mumol/L and ABT-229 contracted this tissue at a threshold concentration of 0.01 mumol/L. Effects of both agonists were antagonized by the motilin receptor antagonists phe3leu13motilin (0.3 mumol/L) and GM-109 (1 mumol/L). 4. It is concluded that the site(s) at which erythromycin acts in the guinea-pig ileum is not a motilin receptor and that ABT-229 is selective for the motilin receptor in comparison with non-motilin erythromycin sites and is unlikely to act at the latter site in therapeutic doses. | en_US |
dc.identifier.issn | 0305-1870 | en_US |
dc.identifier.uri | http://hdl.handle.net/1959.4/40061 | |
dc.language | English | |
dc.language.iso | EN | en_US |
dc.rights | CC BY-NC-ND 3.0 | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/au/ | en_US |
dc.source | Legacy MARC | en_US |
dc.title | An action of erythromycin in the intestine that is not mediated via motilin receptors | en_US |
dc.type | Journal Article | en |
dcterms.accessRights | metadata only access | |
dspace.entity.type | Publication | en_US |
unsw.accessRights.uri | http://purl.org/coar/access_right/c_14cb | |
unsw.identifier.doiPublisher | http://dx.doi.org/10.1046/j.1440-1681.1999.03002.x | en_US |
unsw.relation.faculty | Medicine & Health | |
unsw.relation.ispartofjournal | Clinical and Experimental Pharmacology and Physiology | en_US |
unsw.relation.ispartofpagefrompageto | 100-104 | en_US |
unsw.relation.ispartofvolume | 26 | en_US |
unsw.relation.originalPublicationAffiliation | Furness, J. B. | en_US |
unsw.relation.originalPublicationAffiliation | Clark, M. J. | en_US |
unsw.relation.originalPublicationAffiliation | Wright, T. | en_US |
unsw.relation.originalPublicationAffiliation | Bertrand, P. P, Medical Sciences, Faculty of Medicine, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Bornstein, J. C. | en_US |
unsw.relation.originalPublicationAffiliation | Verlinden, M. | en_US |
unsw.relation.school | School of Medical Sciences | * |