An action of erythromycin in the intestine that is not mediated via motilin receptors Furness, J. B. en_US Clark, M. J. en_US Wright, T. en_US Bertrand, P. P en_US Bornstein, J. C. en_US Verlinden, M. en_US 2021-11-25T13:35:36Z 2021-11-25T13:35:36Z 1999 en_US
dc.description.abstract 1. Erythromycin lactobionate caused a concentration-dependent inhibition of nerve-mediated contractions of the longitudinal muscle of the guinea-pig ileum, with a threshold for effect of 10-30 mumol/L. The non-antibiotic derivative of erythromycin ABT-229 had a similar effect, but was approximately 10-fold less potent. At a greater concentration (1 mmol/L), erythromycin also depressed the direct contractile effect of 10 mumol/L carbachol on the muscle. 2. Human/porcine motilin (up to 100 mumol/L) did not reduce the nerve-mediated contractions, although it did contract the muscle (threshold 30 mumol/L). Antagonists of motilin receptors (phe3leu13motilin, up to 1 mumol/L, and GM-109, up to 3 mumol/L) did not reduce responses to erythromycin. 3. Erythromycin contracted the longitudinal muscle of the rabbit duodenum, with a threshold concentration of 0.1 mumol/L and ABT-229 contracted this tissue at a threshold concentration of 0.01 mumol/L. Effects of both agonists were antagonized by the motilin receptor antagonists phe3leu13motilin (0.3 mumol/L) and GM-109 (1 mumol/L). 4. It is concluded that the site(s) at which erythromycin acts in the guinea-pig ileum is not a motilin receptor and that ABT-229 is selective for the motilin receptor in comparison with non-motilin erythromycin sites and is unlikely to act at the latter site in therapeutic doses. en_US
dc.identifier.issn 0305-1870 en_US
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.title An action of erythromycin in the intestine that is not mediated via motilin receptors en_US
dc.type Journal Article en
dcterms.accessRights metadata only access
dspace.entity.type Publication en_US
unsw.identifier.doiPublisher en_US
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofjournal Clinical and Experimental Pharmacology and Physiology en_US
unsw.relation.ispartofpagefrompageto 100-104 en_US
unsw.relation.ispartofvolume 26 en_US
unsw.relation.originalPublicationAffiliation Furness, J. B. en_US
unsw.relation.originalPublicationAffiliation Clark, M. J. en_US
unsw.relation.originalPublicationAffiliation Wright, T. en_US
unsw.relation.originalPublicationAffiliation Bertrand, P. P, Medical Sciences, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Bornstein, J. C. en_US
unsw.relation.originalPublicationAffiliation Verlinden, M. en_US School of Medical Sciences *
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