Publication:
Is Seladin-1 really a Selective Alzheimer’s Disease Indicator?
Is Seladin-1 really a Selective Alzheimer’s Disease Indicator?
| dc.contributor.author | Wong, Jenny | en_US |
| dc.contributor.author | Garner, Brett | en_US |
| dc.contributor.author | Halliday, Glenda | en_US |
| dc.contributor.author | Sharpe, Laura J | en_US |
| dc.contributor.author | Brown, Andrew J | en_US |
| dc.date.accessioned | 2021-11-25T12:29:23Z | |
| dc.date.available | 2021-11-25T12:29:23Z | |
| dc.date.issued | 2012 | en_US |
| dc.description.abstract | Selective Alzheimer’s Disease Indicator-1 (Seladin-1) was originally identified by its down-regulation in the brains of Alzheimer’s Disease (AD) patients. Here, we re-examine existing data and present new gene expression data that refutes its role as a selective AD indicator. Furthermore, we caution against the use of the name “Seladin-1” and instead recommend adoption of the approved nomenclature, 3â-hydroxysterol Ä24-reductase (or DHCR24), which describes its catalytic function in cholesterol synthesis. Further work is required to determine what link, if any, exists between DHCR24 and AD. | en_US |
| dc.identifier.issn | 1387-2877 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1959.4/53615 | |
| dc.language | English | |
| dc.language.iso | EN | en_US |
| dc.rights | CC BY-NC-ND 3.0 | en_US |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/au/ | en_US |
| dc.source | Legacy MARC | en_US |
| dc.subject.other | Alzheimer’s Disease | en_US |
| dc.subject.other | Seladin-1 | en_US |
| dc.subject.other | DHCR24 | en_US |
| dc.subject.other | cholesterol | en_US |
| dc.subject.other | neuroprotective | en_US |
| dc.subject.other | brain | en_US |
| dc.title | Is Seladin-1 really a Selective Alzheimer’s Disease Indicator? | en_US |
| dc.type | Journal Article | en |
| dcterms.accessRights | open access | |
| dspace.entity.type | Publication | en_US |
| unsw.accessRights.uri | https://purl.org/coar/access_right/c_abf2 | |
| unsw.identifier.doiPublisher | http://dx.doi.org/10.3233/JAD-2012-111955 | en_US |
| unsw.relation.FunderRefNo | 630434 | en_US |
| unsw.relation.faculty | Science | |
| unsw.relation.faculty | Medicine & Health | |
| unsw.relation.fundingScheme | NHMRC Project | en_US |
| unsw.relation.ispartofissue | 1 | en_US |
| unsw.relation.ispartofjournal | Journal of Alzheimer’s disease | en_US |
| unsw.relation.ispartofpagefrompageto | 35-39 | en_US |
| unsw.relation.ispartofvolume | 30 | en_US |
| unsw.relation.originalPublicationAffiliation | Wong, Jenny, Illawarra Health and Medical Research Institute and the School of Biological Sciences, University of Wollongong, Wollongong, NSW, 2522, Australia | en_US |
| unsw.relation.originalPublicationAffiliation | Garner, Brett, Illawarra Health and Medical Research Institute and the School of Biological Sciences, University of Wollongong, Wollongong, NSW, 2522, Australia | en_US |
| unsw.relation.originalPublicationAffiliation | Halliday, Glenda, Neuroscience Research Australia, Faculty of Medicine, UNSW | en_US |
| unsw.relation.originalPublicationAffiliation | Sharpe, Laura J, School of Biotechnology and Biomolecular Sciences, Faculty of Science, UNSW | en_US |
| unsw.relation.originalPublicationAffiliation | Brown, Andrew J, School of Biotechnology and Biomolecular Sciences, Faculty of Science, UNSW | en_US |
| unsw.relation.school | Neuroscience Research Australia | * |
| unsw.relation.school | School of Biotechnology & Biomolecular Sciences | * |
| unsw.subject.fieldofresearchcode | 110903 Central Nervous System | en_US |
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