Is Seladin-1 really a Selective Alzheimer’s Disease Indicator?

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Abstract
Selective Alzheimer’s Disease Indicator-1 (Seladin-1) was originally identified by its down-regulation in the brains of Alzheimer’s Disease (AD) patients. Here, we re-examine existing data and present new gene expression data that refutes its role as a selective AD indicator. Furthermore, we caution against the use of the name “Seladin-1” and instead recommend adoption of the approved nomenclature, 3â-hydroxysterol Ä24-reductase (or DHCR24), which describes its catalytic function in cholesterol synthesis. Further work is required to determine what link, if any, exists between DHCR24 and AD.
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Author(s)
Wong, Jenny
Garner, Brett
Halliday, Glenda
Sharpe, Laura J
Brown, Andrew J
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Publication Year
2012
Resource Type
Journal Article
Degree Type
UNSW Faculty
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