Publication:
Predictors of inotropic and chronotropic effects of NG-monomethyl-L-arginine
Predictors of inotropic and chronotropic effects of NG-monomethyl-L-arginine
dc.contributor.author | O'Sullivan, Anthony | en_US |
dc.contributor.author | Brillante, D | en_US |
dc.contributor.author | Johnstone, M | en_US |
dc.contributor.author | Howes, L | en_US |
dc.date.accessioned | 2021-11-25T14:04:25Z | |
dc.date.available | 2021-11-25T14:04:25Z | |
dc.date.issued | 2009 | en_US |
dc.description.abstract | Background The haemodynamic effects of intravenous infusion of the non-selective nitric oxide synthase (NOS) l-omega monomethyl arginine (l-NMMA) have previously been characterized in humans. Its effect of reducing cardiac index (CI) is an important reason for the increase in mortality in patients with septic shock receiving l-NMMA in a pivotal outcome trial for this indication. The mechanism for the reduction in CI however, is uncertain. Methods In this study, we investigated the haemodynamic and arterial stiffness response to a bolus intravenous infusion of l-NMMA (3 mg kg−1 over 5 min) in 26 healthy human volunteers to clarify the likely cause of l-NMMA induced negative inotropic and chronotropic effects. Digital photoplethysmography (MicroMedical Pulse Trace) was used to derive two measures of arterial stiffness: stiffness index, a measure of large arterial stiffness, and reflection index (RI), a measure of small- to medium-sized arterial stiffness. Haemodynamic measurements of systolic blood pressure, diastolic blood pressure, heart rate, systemic vascular resistance index (SVRI), stroke index and CI were made using a bioimpedance monitor (BioZ Cardiodynamics). Results We found that changes in CI during l-NMMA are closely related to changes in RI and SVRI. Conclusion The negative inotropic effect of l-NMMA may be a result of an increase in coronary vascular resistance and a resultant decrease in myocardial perfusion. The reduction in CI may also result from a direct reduction of the normal positive inotropic effect of NO by l-NMMA which is closely correlated with its effects on SVRI. | en_US |
dc.identifier.issn | 0014-2972 | en_US |
dc.identifier.uri | http://hdl.handle.net/1959.4/41960 | |
dc.language | English | |
dc.language.iso | EN | en_US |
dc.rights | CC BY-NC-ND 3.0 | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/au/ | en_US |
dc.source | Legacy MARC | en_US |
dc.title | Predictors of inotropic and chronotropic effects of NG-monomethyl-L-arginine | en_US |
dc.type | Journal Article | en |
dcterms.accessRights | metadata only access | |
dspace.entity.type | Publication | en_US |
unsw.accessRights.uri | http://purl.org/coar/access_right/c_14cb | |
unsw.description.publisherStatement | The definitive version is available at www3.interscience.wiley.com | en_US |
unsw.identifier.doiPublisher | http://dx.doi.org/10.1111/j.1365-2362.2009.02097.x | en_US |
unsw.relation.faculty | Medicine & Health | |
unsw.relation.faculty | Other UNSW | |
unsw.relation.ispartofjournal | European Journal of Clinical Investigation | en_US |
unsw.relation.ispartofpagefrompageto | 273-279 | en_US |
unsw.relation.ispartofvolume | 39 | en_US |
unsw.relation.originalPublicationAffiliation | O'Sullivan, Anthony, Clinical School - St George Hospital, Faculty of Medicine, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Brillante, D, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Johnstone, M | en_US |
unsw.relation.originalPublicationAffiliation | Howes, L | en_US |
unsw.relation.school | Clinical School St George Hospital | * |