Publication:
MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma
MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma
dc.contributor.author | Brown, David | en_US |
dc.contributor.author | Ward, Robyn | en_US |
dc.contributor.author | Buckhaults, Philip | en_US |
dc.contributor.author | Liu, Tao | en_US |
dc.contributor.author | Romans, Katherine | en_US |
dc.contributor.author | Hawkins, Nicholas | en_US |
dc.contributor.author | Bauskin, Asne | en_US |
dc.contributor.author | Kinzler, Kenneth | en_US |
dc.contributor.author | Vogelstein, Bert | en_US |
dc.contributor.author | Breit, Samuel | en_US |
dc.date.accessioned | 2021-11-25T13:30:22Z | |
dc.date.available | 2021-11-25T13:30:22Z | |
dc.date.issued | 2003 | en_US |
dc.description.abstract | Purpose: Macrophage inhibitory cytokine-1 (MIC-1) is a divergent member of the tumor growth factor ß (TGF-ß) superfamily. Several observations suggest that it plays a role in colorectal carcinoma (CRC). In particular, MIC-1 is markedly up-regulated in colorectal cancers as well as in premalignant adenomas. This study examines the relationship of serum MIC-1 levels and genotypes to clinical and pathologic features of colonic neoplasia. Experimental Design: We confirmed the presence of MIC-1 in CRC tissue and the cell line CaCo-2. The normal range for serum MIC-1 levels was defined in 260 healthy blood donors, and the differences between normal subjects and 193 patients having adenomatous polyps or CRC were then determined. In a separate cohort of 224 patients, we evaluated the relationship of MIC-1 serum level and genotype to standard tumor parameters and outcome measures. Results: MIC-1 was expressed in CRC tissue and the cancer cell line CaCo-2. There was a progressive increase in serum MIC-1 levels between normal individuals [mean (M) = 495 pg/ml, SD = 210), those with adenomatous polyps (M = 681 pg/ml, SD = 410), and those with CRC (M = 783 pg/ml, SD = 491)]. Serum MIC-1 level was correlated with the extent of disease so that the levels were higher in patients with higher Tumor-Node-Metastasis stage. There were significant differences in time to relapse and overall survival between subjects with different MIC-1 levels and genotypes. Conclusions: This study identifies a strong association between MIC-1 serum levels and neoplastic progression within the large bowel. We suggest that the measurement of serum MIC-1 levels and determination of MIC-1 genotype may have clinical use in the management of patients with CRC. | en_US |
dc.description.uri | http://clincancerres.aacrjournals.org/cgi/content/abstract/9/7/2642 | en_US |
dc.identifier.issn | 1078-0432 | en_US |
dc.identifier.uri | http://hdl.handle.net/1959.4/39780 | |
dc.language | English | |
dc.language.iso | EN | en_US |
dc.rights | CC BY-NC-ND 3.0 | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/au/ | en_US |
dc.source | Legacy MARC | en_US |
dc.title | MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma | en_US |
dc.type | Journal Article | en |
dcterms.accessRights | metadata only access | |
dspace.entity.type | Publication | en_US |
unsw.accessRights.uri | http://purl.org/coar/access_right/c_14cb | |
unsw.relation.faculty | Medicine & Health | |
unsw.relation.faculty | Science | |
unsw.relation.ispartofjournal | Clin Cancer Res | en_US |
unsw.relation.ispartofpagefrompageto | 2642-2650 | en_US |
unsw.relation.ispartofvolume | 9 | en_US |
unsw.relation.originalPublicationAffiliation | Brown, David, Clinical School - St Vincent's Hospital, Faculty of Medicine, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Ward, Robyn, Clinical School - St Vincent's Hospital, Faculty of Medicine, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Buckhaults, Philip | en_US |
unsw.relation.originalPublicationAffiliation | Liu, Tao, Clinical School - St Vincent's Hospital, Faculty of Medicine, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Romans, Katherine | en_US |
unsw.relation.originalPublicationAffiliation | Hawkins, Nicholas, Medical Sciences, Faculty of Medicine, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Bauskin, Asne, Centre for Immunology, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Kinzler, Kenneth | en_US |
unsw.relation.originalPublicationAffiliation | Vogelstein, Bert | en_US |
unsw.relation.originalPublicationAffiliation | Breit, Samuel, Centre for Immunology, UNSW | en_US |
unsw.relation.school | Clinical School St Vincents Hospital | * |
unsw.relation.school | School of Medical Sciences | * |