Publication:
Multiple Levels of Sensory Integration in the Intrinsic Sensory Neurons of the Enteric Nervous System

dc.contributor.author Bertrand, P. P en_US
dc.contributor.author Thomas, E. A. en_US
dc.date.accessioned 2021-11-25T13:35:16Z
dc.date.available 2021-11-25T13:35:16Z
dc.date.issued 2004 en_US
dc.description.abstract 1. The enteric nervous system (ENS) is present in the wall of the gastrointestinal tract and contains all the functional classes of neuron required for complete reflex arcs. One of the most important and intriguing classes of neuron is that responsive to sensory stimuli: sensory neurons with cell bodies intrinsic to the ENS. 2. These neurons have three outstanding and interrelated features: (i) reciprocal connections with each other; (ii) a slow excitatory post-synaptic potential (EPSP) resulting from high-speed firing in other sensory neurons; and (iii) a large after-hyperpolarizing potential (AHP) at the soma. Slow EPSP depolarize the cell body, generate action potentials (APs) and reduce the AHP. Conversely, the AHP limits the firing rate and, hence, reduces transmission of slow EPSP. 3. Processing of sensory information starts at the input terminals as different patterns of APs depending on the sensory modality and recent sensory history. At the soma, the ability to fire APs and, hence, drive outputs is also strongly determined by the recent firing history of the neuron (through the AHP) and network activity (through the slow EPSP). Positive feedback within the population of intrinsic sensory neurons means that the network is able to drive outputs well beyond the duration of the stimuli that triggered them. 4. Thus, sensory input and subsequent reflex generation are integrated over several hierarchical levels within the network on intrinsic sensory neurons. en_US
dc.identifier.issn 0305-1870 en_US
dc.identifier.uri http://hdl.handle.net/1959.4/40045
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/3.0/au/ en_US
dc.source Legacy MARC en_US
dc.title Multiple Levels of Sensory Integration in the Intrinsic Sensory Neurons of the Enteric Nervous System en_US
dc.type Journal Article en
dcterms.accessRights metadata only access
dspace.entity.type Publication en_US
unsw.accessRights.uri http://purl.org/coar/access_right/c_14cb
unsw.identifier.doiPublisher http://dx.doi.org/10.1111/j.1440-1681.2004.04092.x en_US
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofissue 11 en_US
unsw.relation.ispartofjournal Clinical and Experimental Pharmacology and Physiology en_US
unsw.relation.ispartofpagefrompageto 745-755 en_US
unsw.relation.ispartofvolume 31 en_US
unsw.relation.originalPublicationAffiliation Bertrand, P. P, Medical Sciences, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Thomas, E. A. en_US
unsw.relation.school School of Medical Sciences *
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