Publication:
Stepwise synthesis of gly-gly-his on gold surfaces modified with mixed self-assembled monolayers
Stepwise synthesis of gly-gly-his on gold surfaces modified with mixed self-assembled monolayers
dc.contributor.author | Yang, Wenrong | en_US |
dc.contributor.author | Hibbert, D. Brynn | en_US |
dc.contributor.author | Zhang, Rui | en_US |
dc.contributor.author | Willett, Gary | en_US |
dc.contributor.author | Gooding, John | en_US |
dc.date.accessioned | 2021-11-25T12:51:47Z | |
dc.date.available | 2021-11-25T12:51:47Z | |
dc.date.issued | 2005 | en_US |
dc.description.abstract | Peptide-modified electrode surfaces have been shown to have excellent recognition properties for metal ions. An efficient method of screening a potential peptide for its selectivity for a given metal would involve the synthesis of the peptide directly on the electrode surface. This paper outlines a procedure in which the tripeptide Gly-Gly-His was synthesized one amino acid at a time on a gold surface modified with a self-assembled monolayer of the mixed alkanethiolates 3-mercaptopropionic acid (MPA) and 3-mercaptopropane (MP). Electrochemistry and high-resolution mass spectrometry were used to elucidate the structure of the adsorbed species and follow the synthesis. The amino acids can be attached only to MPA, but the presence of a diluting unreactive molecule of MP reduces steric crowding about the reaction center. The maximum coverage of synthesized tripeptide occurs at a ratio of MPA/MP of 1:1. | en_US |
dc.identifier.issn | 0743-7463 | en_US |
dc.identifier.uri | http://hdl.handle.net/1959.4/38367 | |
dc.language | English | |
dc.language.iso | EN | en_US |
dc.rights | CC BY-NC-ND 3.0 | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/au/ | en_US |
dc.source | Legacy MARC | en_US |
dc.title | Stepwise synthesis of gly-gly-his on gold surfaces modified with mixed self-assembled monolayers | en_US |
dc.type | Journal Article | en |
dcterms.accessRights | metadata only access | |
dspace.entity.type | Publication | en_US |
unsw.accessRights.uri | http://purl.org/coar/access_right/c_14cb | |
unsw.relation.faculty | Science | |
unsw.relation.ispartofissue | 1 | en_US |
unsw.relation.ispartofjournal | Langmuir | en_US |
unsw.relation.ispartofpagefrompageto | 260-265 | en_US |
unsw.relation.ispartofvolume | 21 | en_US |
unsw.relation.originalPublicationAffiliation | Yang, Wenrong, Chemistry, Faculty of Science, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Hibbert, D. Brynn, Chemistry, Faculty of Science, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Zhang, Rui, Chemistry, Faculty of Science, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Willett, Gary, Chemistry, Faculty of Science, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Gooding, John, Chemistry, Faculty of Science, UNSW | en_US |
unsw.relation.school | School of Chemistry | * |