Psychological impact of genetic testing for cancer susceptibility: an update of the literature Meiser, Bettina en_US 2021-11-25T13:01:48Z 2021-11-25T13:01:48Z 2005 en_US
dc.description.abstract This article presents an overview of the rapidly evolving body of literature on the psychological impact of genetic testing for hereditary breast/ovarian cancer susceptibility, hereditary non-polyposis colorectal cancer (HNPCC) and familial adenomatous polyposis (FAP). Uptake of genetic testing for BRCA1/2 and HNPCC-related mutations is more consistently related to psychological factors, rather than sociodemographic variables. Most studies on the psychological impact of genetic testing amongst individuals who have never been affected by cancer demonstrate that non-carriers derive significant psychological benefits from genetic testing, while no adverse effects have been observed amongst carriers. These benefits are more clear-cut for HNPCC, compared to hereditary breast/ovarian cancer, reflecting differences in risk management options. The few studies available on individuals affected with cancer indicate that the impact of genetic testing is mediated and amplified by their former experience of cancer. Future directions and challenges of research in this area are reviewed. In particular, more empirical data are needed on the broader impact of genetic testing on those with inconclusive results or results of uncertain significance. As genetic testing is becoming available for other types of familial cancer, additional investigations will be needed as there is evidence to suggest that the impact of genetic testing may be unique to each type of familial cancer. Copyright # 2005 John Wiley & Sons, Ltd. en_US
dc.identifier.issn 1057-9249 en_US
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.subject.other hereditary breast/ovarian cancer en_US
dc.subject.other hereditary non-polyposis colorectal cancer (HNPCC) en_US
dc.subject.other familial adenomatous polyposis (FAP) en_US
dc.subject.other hereditary melanoma en_US
dc.subject.other impact of genetic testing en_US
dc.title Psychological impact of genetic testing for cancer susceptibility: an update of the literature en_US
dc.type Journal Article en
dcterms.accessRights metadata only access
dspace.entity.type Publication en_US
unsw.description.notePublic Copyright © 2000-2008 en_US
unsw.identifier.doiPublisher en_US
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofissue 12 en_US
unsw.relation.ispartofjournal Psycho-Oncology: Journal of the psychological,social and behavioural dimensions of cancer en_US
unsw.relation.ispartofpagefrompageto 1060-1074 en_US
unsw.relation.ispartofvolume 14 en_US
unsw.relation.originalPublicationAffiliation Meiser, Bettina, Prince of Wales Clinical School, Faculty of Medicine, UNSW en_US Clinical School Prince of Wales Hospital *
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