Colorectal cancer: a model for epigenetic tumorigenesis

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Abstract
Recent advances in basic and clinical science have driven epigenetics to the forefront of cancer research. Together with genetic changes, the disruption of epigenetic mechanisms is now established as a hallmark of cancer in humans. Colorectal cancer, long a classic model for the genetic basis of cancer, is now providing researchers with the opportunity to view epigenetic events in the context of neoplasia in humans. Knowledge of the heritable changes in gene expression that result from epigenetic events is of increasing relevance to clinical practice, particularly in terms of diagnostic and prognostic molecular markers, as well as novel therapeutic targets.
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Author(s)
Wong, Justin
Hawkins, Nicholas
Ward, Robyn
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Publication Year
2007
Resource Type
Journal Article
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UNSW Faculty
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download Wong 2007 Gut.pdf 316.1 KB Adobe Portable Document Format
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