Publication:
Psychological impact of genetic testing in women from high risk breast cancer families
Psychological impact of genetic testing in women from high risk breast cancer families
dc.contributor.author | Meiser, Bettina | en_US |
dc.contributor.author | Butow, P. | en_US |
dc.contributor.author | Friedlander, Michael | en_US |
dc.contributor.author | Barratt, Anthony | en_US |
dc.contributor.author | Schnieden, Vivienne | en_US |
dc.contributor.author | Watson, M | en_US |
dc.contributor.author | Brown, J | en_US |
dc.contributor.author | Tucker, K | en_US |
dc.date.accessioned | 2021-11-25T12:59:54Z | |
dc.date.available | 2021-11-25T12:59:54Z | |
dc.date.issued | 2002 | en_US |
dc.description.abstract | Psychological adjustment in 90 women (30 carriers and 60 non-carriers) who had undergone genetic testing for mutations in BRCA1 and BRCA2 breast/ovarian cancer susceptibility genes was compared with that of 53 women who were not offered genetic testing. Women were assessed prior to genetic testing and 7–10 days, 4 and 12 months after carrier status disclosure using self-administered questionnaires. Compared with women not offered testing, mutation carriers had significantly higher breast cancer distress 7–10 days (t=2.80, P=0.005) and 12 months (t=2.01, P=0.045) post-notification. Non-carriers showed a significant decrease in state anxiety 7–10 days post-notification (t=2.27, P=0.024) and in depression 4 months post-notification (t=2.26, P=0.024), compared with women not offered testing. These data show that non-carriers derive psychological benefits from genetic testing. Women testing positive may anticipate a sustained increase in breast cancer distress following disclosure, although no other adverse psychological outcomes were observed in this group. | en_US |
dc.identifier.issn | 0959-8049 | en_US |
dc.identifier.uri | http://hdl.handle.net/1959.4/38885 | |
dc.language | English | |
dc.language.iso | EN | en_US |
dc.rights | CC BY-NC-ND 3.0 | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/au/ | en_US |
dc.source | Legacy MARC | en_US |
dc.subject.other | Hereditary breast cancer | en_US |
dc.subject.other | Psychological impact | en_US |
dc.subject.other | Genetic counselling | en_US |
dc.title | Psychological impact of genetic testing in women from high risk breast cancer families | en_US |
dc.type | Journal Article | en |
dcterms.accessRights | metadata only access | |
dspace.entity.type | Publication | en_US |
unsw.accessRights.uri | http://purl.org/coar/access_right/c_14cb | |
unsw.identifier.doiPublisher | http://dx.doi.org/10.1016/S0959-8049(02)00264-2 | en_US |
unsw.relation.faculty | Medicine & Health | |
unsw.relation.faculty | Arts Design & Architecture | |
unsw.relation.ispartofissue | 15 | en_US |
unsw.relation.ispartofjournal | European Journal of Cancer | en_US |
unsw.relation.ispartofpagefrompageto | 2025-2031 | en_US |
unsw.relation.ispartofvolume | 38 | en_US |
unsw.relation.originalPublicationAffiliation | Meiser, Bettina, Prince of Wales Clinical School, Faculty of Medicine, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Butow, P., Medical Psychology Unit, University of Sydney | en_US |
unsw.relation.originalPublicationAffiliation | Friedlander, Michael, Prince of Wales Clinical School, Faculty of Medicine, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Barratt, Anthony, Public Health & Community Medicine, University of Sydney | en_US |
unsw.relation.originalPublicationAffiliation | Schnieden, Vivienne, Prince of Wales Clinical School, Faculty of Medicine, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Watson, M, Royal Marsden Hospital and Institute of Cancer Research | en_US |
unsw.relation.originalPublicationAffiliation | Brown, J, Social Policy Research Centre, Faculty of Arts & Social Sciences, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Tucker, K, Clinical School - Prince of Wales Hospital, Faculty of Medicine, UNSW | en_US |
unsw.relation.school | Clinical School Prince of Wales Hospital | * |
unsw.relation.school | Social Policy Research Centre | * |