Publication:
Design and synthesis of á-helical peptides and mimetics
Design and synthesis of á-helical peptides and mimetics
dc.contributor.author | Garner, James | en_US |
dc.contributor.author | Harding, Margaret | en_US |
dc.date.accessioned | 2021-11-25T13:30:31Z | |
dc.date.available | 2021-11-25T13:30:31Z | |
dc.date.issued | 2007 | en_US |
dc.description.abstract | The á-helix is the most abundant secondary structural element in proteins and is an important structural domain for mediating protein-protein and protein-nucleic acid interactions. Strategies for the rational design and synthesis of á-helix mimetics have not matured as well as other secondary structure mimetics such as strands and turns. This perspective will focus on developments in the design, synthesis and applications of á-helices and mimetics, particularly in the last 5 years. Examples where synthetic compounds have delivered promising biological results will be highlighted as well as opportunities for the design of mimetics of the type I á-helical antifreeze proteins. © The Royal Society of Chemistry. | en_US |
dc.identifier.issn | 1477-0520 | en_US |
dc.identifier.uri | http://hdl.handle.net/1959.4/39836 | |
dc.language | English | |
dc.language.iso | EN | en_US |
dc.rights | CC BY-NC-ND 3.0 | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/au/ | en_US |
dc.source | Legacy MARC | en_US |
dc.subject.other | Peptides | en_US |
dc.subject.other | Antifreeze solutions | en_US |
dc.subject.other | Bioactivity | en_US |
dc.subject.other | Nucleic acids | en_US |
dc.subject.other | Synthesis (chemical) | en_US |
dc.title | Design and synthesis of á-helical peptides and mimetics | en_US |
dc.type | Journal Article | en |
dcterms.accessRights | metadata only access | |
dspace.entity.type | Publication | en_US |
unsw.accessRights.uri | http://purl.org/coar/access_right/c_14cb | |
unsw.identifier.doiPublisher | http://dx.doi.org/10.1039/b710425a | en_US |
unsw.relation.faculty | Science | |
unsw.relation.ispartofissue | 22 | en_US |
unsw.relation.ispartofjournal | Organic and Biomolecular Chemistry | en_US |
unsw.relation.ispartofpagefrompageto | 3577-3585 | en_US |
unsw.relation.ispartofvolume | 5 | en_US |
unsw.relation.originalPublicationAffiliation | Garner, James, Chemistry, Faculty of Science, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Harding, Margaret, Chemistry, Faculty of Science, UNSW | en_US |
unsw.relation.school | School of Chemistry | * |