Publication:
Design and synthesis of á-helical peptides and mimetics

dc.contributor.author Garner, James en_US
dc.contributor.author Harding, Margaret en_US
dc.date.accessioned 2021-11-25T13:30:31Z
dc.date.available 2021-11-25T13:30:31Z
dc.date.issued 2007 en_US
dc.description.abstract The á-helix is the most abundant secondary structural element in proteins and is an important structural domain for mediating protein-protein and protein-nucleic acid interactions. Strategies for the rational design and synthesis of á-helix mimetics have not matured as well as other secondary structure mimetics such as strands and turns. This perspective will focus on developments in the design, synthesis and applications of á-helices and mimetics, particularly in the last 5 years. Examples where synthetic compounds have delivered promising biological results will be highlighted as well as opportunities for the design of mimetics of the type I á-helical antifreeze proteins. © The Royal Society of Chemistry. en_US
dc.identifier.issn 1477-0520 en_US
dc.identifier.uri http://hdl.handle.net/1959.4/39836
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/3.0/au/ en_US
dc.source Legacy MARC en_US
dc.subject.other Peptides en_US
dc.subject.other Antifreeze solutions en_US
dc.subject.other Bioactivity en_US
dc.subject.other Nucleic acids en_US
dc.subject.other Synthesis (chemical) en_US
dc.title Design and synthesis of á-helical peptides and mimetics en_US
dc.type Journal Article en
dcterms.accessRights metadata only access
dspace.entity.type Publication en_US
unsw.accessRights.uri http://purl.org/coar/access_right/c_14cb
unsw.identifier.doiPublisher http://dx.doi.org/10.1039/b710425a en_US
unsw.relation.faculty Science
unsw.relation.ispartofissue 22 en_US
unsw.relation.ispartofjournal Organic and Biomolecular Chemistry en_US
unsw.relation.ispartofpagefrompageto 3577-3585 en_US
unsw.relation.ispartofvolume 5 en_US
unsw.relation.originalPublicationAffiliation Garner, James, Chemistry, Faculty of Science, UNSW en_US
unsw.relation.originalPublicationAffiliation Harding, Margaret, Chemistry, Faculty of Science, UNSW en_US
unsw.relation.school School of Chemistry *
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