Publication:
Circumcision and risk of sexually transmissible infections in a community-based cohort of HIV-negative homosexual men in Sydney, Australia

dc.contributor.author Grulich, Andrew en_US
dc.contributor.author Templeton, David en_US
dc.contributor.author Jin, Feng Yi en_US
dc.contributor.author Prestage, Garrett en_US
dc.contributor.author Donovan, Basil en_US
dc.contributor.author Imrie, John en_US
dc.contributor.author Kippax, Susan en_US
dc.contributor.author Cunningham, Philip en_US
dc.contributor.author Kaldor, John en_US
dc.contributor.author Mindel, Adrian en_US
dc.contributor.author Cunningham, Anthony en_US
dc.date.accessioned 2021-11-25T15:43:34Z
dc.date.available 2021-11-25T15:43:34Z
dc.date.issued 2009 en_US
dc.description.abstract BACKGROUND: Circumcision status was examined as an independent risk factor for sexually transmissible infections (STIs) in the Health in Men cohort of homosexual men in Sydney. METHODS: From 2001 through 2004, 1427 initially human immunodeficiency virus (HIV)-negative men were enrolled and followed up until mid-2007. All participants were offered annual STI testing. The history of STIs was collected at baseline, and information on sexual risk behaviors was collected every 6 months. At annual face-to-face visits, participants reported STI diagnoses received during the previous year. RESULTS: Circumcision was not associated with prevalent or incident herpes simplex virus 1, herpes simplex virus 2, or self-reported genital warts. There was also no independent association of circumcision with incident urethral gonorrhea or chlamydia. Being circumcised was associated with a significantly reduced risk of incident (hazard ratio, 0.35 [95% confidence interval, 0.15-0.84]) but not prevalent (odds ratio, 0.71 [95% confidence interval, 0.35-1.44]) syphilis. The association was somewhat stronger among men who reported predominantly insertive unprotected anal intercourse (hazard ratio, 0.10 [95% confidence interval, 0.01-0.82]). CONCLUSIONS: These are the first prospective data obtained from homosexual men to assess circumcision status as a risk factor for STIs. Circumcised men were at reduced risk of incident syphilis but no other prevalent or incident STIs. Circumcision is unlikely to have a substantial public health impact in reducing acquisition of most STIs in homosexual men. en_US
dc.identifier.issn 0022-1899 en_US
dc.identifier.uri http://hdl.handle.net/1959.4/44925
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/3.0/au/ en_US
dc.source Legacy MARC en_US
dc.subject.other CLINICAL SCIENCES (FORC:110300) en_US
dc.subject.other risk factors en_US
dc.subject.other Sexually transmissible infections en_US
dc.subject.other homosexual men en_US
dc.subject.other risk behaviour en_US
dc.subject.other circumcision en_US
dc.subject.other STI en_US
dc.subject.other STD en_US
dc.title Circumcision and risk of sexually transmissible infections in a community-based cohort of HIV-negative homosexual men in Sydney, Australia en_US
dc.type Journal Article en
dcterms.accessRights metadata only access
dspace.entity.type Publication en_US
unsw.accessRights.uri http://purl.org/coar/access_right/c_14cb
unsw.description.notePublic Published by University of Chicago Press, Chicago, IL, USA en_US
unsw.identifier.doiPublisher http://dx.doi.org/10.1086/648376 en_US
unsw.relation.faculty Medicine & Health
unsw.relation.faculty Other UNSW
unsw.relation.faculty Science
unsw.relation.faculty Arts Design & Architecture
unsw.relation.ispartofissue 12 en_US
unsw.relation.ispartofjournal Journal of Infectious Diseases en_US
unsw.relation.ispartofpagefrompageto 1813-1819 en_US
unsw.relation.ispartofvolume 200 en_US
unsw.relation.originalPublicationAffiliation Grulich, Andrew, National Centre in HIV Epidemiology & Clinical Research, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Templeton, David, National Centre in HIV Epidemiology & Clinical Research, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Jin, Feng Yi, National Centre in HIV Epidemiology & Clinical Research, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Prestage, Garrett, National Centre in HIV Epidemiology & Clinical Research, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Donovan, Basil, National Centre in HIV Epidemiology & Clinical Research, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Imrie, John, National Centre in HIV Social Research, Faculty of Arts & Social Sciences, UNSW en_US
unsw.relation.originalPublicationAffiliation Kippax, Susan, National Centre in HIV Social Research, Faculty of Arts & Social Sciences, UNSW en_US
unsw.relation.originalPublicationAffiliation Cunningham, Philip, Centre for Immunology, UNSW en_US
unsw.relation.originalPublicationAffiliation Kaldor, John, National Centre in HIV Epidemiology & Clinical Research, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Mindel, Adrian, UNSW en_US
unsw.relation.originalPublicationAffiliation Cunningham, Anthony, UNSW en_US
unsw.relation.school The Kirby Institute *
unsw.relation.school Centre for Social Research in Health *
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