Publication:
Circumcision and risk of sexually transmissible infections in a community-based cohort of HIV-negative homosexual men in Sydney, Australia
Circumcision and risk of sexually transmissible infections in a community-based cohort of HIV-negative homosexual men in Sydney, Australia
dc.contributor.author | Grulich, Andrew | en_US |
dc.contributor.author | Templeton, David | en_US |
dc.contributor.author | Jin, Feng Yi | en_US |
dc.contributor.author | Prestage, Garrett | en_US |
dc.contributor.author | Donovan, Basil | en_US |
dc.contributor.author | Imrie, John | en_US |
dc.contributor.author | Kippax, Susan | en_US |
dc.contributor.author | Cunningham, Philip | en_US |
dc.contributor.author | Kaldor, John | en_US |
dc.contributor.author | Mindel, Adrian | en_US |
dc.contributor.author | Cunningham, Anthony | en_US |
dc.date.accessioned | 2021-11-25T15:43:34Z | |
dc.date.available | 2021-11-25T15:43:34Z | |
dc.date.issued | 2009 | en_US |
dc.description.abstract | BACKGROUND: Circumcision status was examined as an independent risk factor for sexually transmissible infections (STIs) in the Health in Men cohort of homosexual men in Sydney. METHODS: From 2001 through 2004, 1427 initially human immunodeficiency virus (HIV)-negative men were enrolled and followed up until mid-2007. All participants were offered annual STI testing. The history of STIs was collected at baseline, and information on sexual risk behaviors was collected every 6 months. At annual face-to-face visits, participants reported STI diagnoses received during the previous year. RESULTS: Circumcision was not associated with prevalent or incident herpes simplex virus 1, herpes simplex virus 2, or self-reported genital warts. There was also no independent association of circumcision with incident urethral gonorrhea or chlamydia. Being circumcised was associated with a significantly reduced risk of incident (hazard ratio, 0.35 [95% confidence interval, 0.15-0.84]) but not prevalent (odds ratio, 0.71 [95% confidence interval, 0.35-1.44]) syphilis. The association was somewhat stronger among men who reported predominantly insertive unprotected anal intercourse (hazard ratio, 0.10 [95% confidence interval, 0.01-0.82]). CONCLUSIONS: These are the first prospective data obtained from homosexual men to assess circumcision status as a risk factor for STIs. Circumcised men were at reduced risk of incident syphilis but no other prevalent or incident STIs. Circumcision is unlikely to have a substantial public health impact in reducing acquisition of most STIs in homosexual men. | en_US |
dc.identifier.issn | 0022-1899 | en_US |
dc.identifier.uri | http://hdl.handle.net/1959.4/44925 | |
dc.language | English | |
dc.language.iso | EN | en_US |
dc.rights | CC BY-NC-ND 3.0 | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/au/ | en_US |
dc.source | Legacy MARC | en_US |
dc.subject.other | CLINICAL SCIENCES (FORC:110300) | en_US |
dc.subject.other | risk factors | en_US |
dc.subject.other | Sexually transmissible infections | en_US |
dc.subject.other | homosexual men | en_US |
dc.subject.other | risk behaviour | en_US |
dc.subject.other | circumcision | en_US |
dc.subject.other | STI | en_US |
dc.subject.other | STD | en_US |
dc.title | Circumcision and risk of sexually transmissible infections in a community-based cohort of HIV-negative homosexual men in Sydney, Australia | en_US |
dc.type | Journal Article | en |
dcterms.accessRights | metadata only access | |
dspace.entity.type | Publication | en_US |
unsw.accessRights.uri | http://purl.org/coar/access_right/c_14cb | |
unsw.description.notePublic | Published by University of Chicago Press, Chicago, IL, USA | en_US |
unsw.identifier.doiPublisher | http://dx.doi.org/10.1086/648376 | en_US |
unsw.relation.faculty | Medicine & Health | |
unsw.relation.faculty | Other UNSW | |
unsw.relation.faculty | Science | |
unsw.relation.faculty | Arts Design & Architecture | |
unsw.relation.ispartofissue | 12 | en_US |
unsw.relation.ispartofjournal | Journal of Infectious Diseases | en_US |
unsw.relation.ispartofpagefrompageto | 1813-1819 | en_US |
unsw.relation.ispartofvolume | 200 | en_US |
unsw.relation.originalPublicationAffiliation | Grulich, Andrew, National Centre in HIV Epidemiology & Clinical Research, Faculty of Medicine, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Templeton, David, National Centre in HIV Epidemiology & Clinical Research, Faculty of Medicine, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Jin, Feng Yi, National Centre in HIV Epidemiology & Clinical Research, Faculty of Medicine, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Prestage, Garrett, National Centre in HIV Epidemiology & Clinical Research, Faculty of Medicine, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Donovan, Basil, National Centre in HIV Epidemiology & Clinical Research, Faculty of Medicine, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Imrie, John, National Centre in HIV Social Research, Faculty of Arts & Social Sciences, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Kippax, Susan, National Centre in HIV Social Research, Faculty of Arts & Social Sciences, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Cunningham, Philip, Centre for Immunology, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Kaldor, John, National Centre in HIV Epidemiology & Clinical Research, Faculty of Medicine, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Mindel, Adrian, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Cunningham, Anthony, UNSW | en_US |
unsw.relation.school | The Kirby Institute | * |
unsw.relation.school | Centre for Social Research in Health | * |