The impact of predictive genetic testing for hereditary nonpolyposis colorectal cancer: three years after testing Collins, V en_US Meiser, Bettina en_US Ukoumunne, O en_US Gaff, C en_US John, D en_US Halliday, Jane en_US 2021-11-25T12:58:11Z 2021-11-25T12:58:11Z 2007 en_US
dc.description.abstract Background: To fully assess predictive genetic testing programs, it is important to assess outcomes over periods of time longer than the 1-year follow-up reported in the literature. Methods: We conducted a 3-year study of individuals who received predictive genetic test results for previously identified familial mutations in Australian Familial Cancer Clinics. Questionnaires were sent before attendance at the familial cancer clinic and 2 weeks, 4 months, 1 year, and 3 years after receiving test results. Psychological measures were included each time, and preventive behaviors were assessed at baseline and I and 3 years. Psychological measures were adjusted for age, gender, and baseline score. Results: The study included 19 carriers and 54 non-carriers. We previously reported an increase in mean cancer-specific distress in carriers at 2 weeks with a return to baseline levels by 12 months. This level was maintained until 3 years. Non-carriers showed sustained decreases after testing with a significantly lower level at 3 years compared with baseline (P < 0.001). These scores tended to be lower than those for carriers at 3 years (P = 0.09). Mean depression and anxiety scores did not differ between carriers and non-carriers and, at 3 years, were similar to baseline. All carriers and 7% of non-carriers had had a colonoscopy by 3 years, and 69% of 13 female carriers had undergone gynecological screening in the previous 2 years. Prophylactic surgery was rare. Conclusion: This report of long-term data indicates appropriate screening and improved psychological measures for non-carriers with no evidence of undue psychological distress in carriers of hereditary nonpolyposis colorectal cancer mutations. en_US
dc.identifier.issn 1098-3600 en_US
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.subject.other hereditary nonpolyposis colorectal cancer en_US
dc.subject.other genetic testing en_US
dc.subject.other psychological impact en_US
dc.subject.other colonoscopy en_US
dc.subject.other endometrial cancer en_US
dc.title The impact of predictive genetic testing for hereditary nonpolyposis colorectal cancer: three years after testing en_US
dc.type Journal Article en
dcterms.accessRights metadata only access
dspace.entity.type Publication en_US
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofissue 5 en_US
unsw.relation.ispartofjournal Genetics in Medicine en_US
unsw.relation.ispartofpagefrompageto 290-297 en_US
unsw.relation.ispartofvolume 9 en_US
unsw.relation.originalPublicationAffiliation Collins, V en_US
unsw.relation.originalPublicationAffiliation Meiser, Bettina, Prince of Wales Clinical School, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Ukoumunne, O en_US
unsw.relation.originalPublicationAffiliation Gaff, C en_US
unsw.relation.originalPublicationAffiliation John, D en_US
unsw.relation.originalPublicationAffiliation Halliday, Jane en_US Clinical School Prince of Wales Hospital *
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