Electrophysiology, shape and chemistry of intestinofugal neurons projecting from guinea pig distal colon to inferior mesenteric ganglia Sharkey, K. A. en_US Lomax, A. E. en_US Bertrand, P. P en_US Furness, J. B. en_US 2021-11-25T13:34:41Z 2021-11-25T13:34:41Z 1998 en_US
dc.description.abstract BACKGROUND & AIMS: Prevertebral sympathetic ganglia receive inputs from intestinofugal neurons, with cell bodies located in the wall of the bowel. Intestinofugal neurons are part of the afferent limbs of intestino-intestinal reflexes. The aim of this study was to define the properties of intestinofugal neurons using intracellular recordings. METHODS: Intestinofugal neurons of the distal colon were retrogradely labeled from the inferior mesenteric ganglia. In whole mounts of the myenteric plexus/longitudinal muscle of the distal colon, labeled neurons were identified by their fluorescence and recordings were made using biocytin-filled electrodes. Labeled nerves were characterized immunohistochemically and morphologically. RESULTS: Intestinofugal neurons were uniaxonal neurons with multiple dendrites that had lamellar expansions. They were immunoreactive for choline acetyltransferase. Stimulation of nerve fiber tracts elicited large-amplitude excitatory postsynaptic potentials in all labeled neurons. Some received spontaneous fast excitatory postsynaptic potentials. Those cells that fired action potentials fired only one or two at the start of a depolarizing current pulse. No intestinofugal neurons had Dogiel type II morphology or a late afterhyperpolarizing potential. CONCLUSIONS: Intestinofugal neurons are likely to be activated by other neurons in the gut wall. They are not AH or Dogiel type II neurons. Thus they seem to be second order neurons in afferent pathways of intestino-intestinal reflexes. en_US
dc.description.uri en_US
dc.identifier.issn 0016-5085 en_US
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.title Electrophysiology, shape and chemistry of intestinofugal neurons projecting from guinea pig distal colon to inferior mesenteric ganglia en_US
dc.type Journal Article en
dcterms.accessRights metadata only access
dspace.entity.type Publication en_US
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofjournal Gastroenterology en_US
unsw.relation.ispartofpagefrompageto 909-918 en_US
unsw.relation.ispartofvolume 115 en_US
unsw.relation.originalPublicationAffiliation Sharkey, K. A. en_US
unsw.relation.originalPublicationAffiliation Lomax, A. E. en_US
unsw.relation.originalPublicationAffiliation Bertrand, P. P, Medical Sciences, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Furness, J. B. en_US School of Medical Sciences *
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