Promotion of Cellular NAD+ Anabolism: Therapeutic Potential for Oxidative Stress in Ageing and Alzheimer's Disease Braidy, Nady en_US Guillemin, Gilles en_US Grant, Ross en_US 2021-11-25T12:37:44Z 2021-11-25T12:37:44Z 2008 en_US
dc.description.abstract Oxidative imbalance is a prominent feature in Alzheimer's disease and ageing. Increased levels of reactive oxygen species (ROS) can result in disordered cellular metabolism due to lipid peroxidation, protein-cross linking, DNA damage and the depletion of nicotinamide adenine dinucleotide (NAD+). NAD+ is a ubiquitous pyridine nucleotide that plays an essential role in important biological reactions, from ATP production and secondary messenger signalling, to transcriptional regulation and DNA repair. Chronic oxidative stress may be associated with NAD+ depletion and a subsequent decrease in metabolic regulation and cell viability. Hence, therapies targeted toward maintaining intracellular NAD+ pools may prove efficacious in the protection of age-dependent cellular damage, in general, and neurodegeneration in chronic central nervous system inflammatory diseases such as Alzheimer's disease, in particular. en_US
dc.identifier.issn 1029-8428 en_US
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.subject.other oxidative stress en_US
dc.subject.other NAD en_US
dc.subject.other neurodegenerative en_US
dc.subject.other Medical and Health Sciences not elsewhere classified (329999) en_US
dc.title Promotion of Cellular NAD+ Anabolism: Therapeutic Potential for Oxidative Stress in Ageing and Alzheimer's Disease en_US
dc.type Journal Article en
dcterms.accessRights open access
dspace.entity.type Publication en_US
unsw.description.publisherStatement Published version available via: en_US
unsw.relation.faculty Other UNSW
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofissue 4 en_US
unsw.relation.ispartofjournal Neurotoxicity Research en_US
unsw.relation.ispartofpagefrompageto 173-184 en_US
unsw.relation.ispartofvolume 13 en_US
unsw.relation.originalPublicationAffiliation Braidy, Nady, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Guillemin, Gilles, UNSW en_US
unsw.relation.originalPublicationAffiliation Grant, Ross, Medical Sciences, Faculty of Medicine, UNSW en_US School of Medical Sciences *
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