Publication:
Promotion of Cellular NAD+ Anabolism: Therapeutic Potential for Oxidative Stress in Ageing and Alzheimer's Disease
Promotion of Cellular NAD+ Anabolism: Therapeutic Potential for Oxidative Stress in Ageing and Alzheimer's Disease
dc.contributor.author | Braidy, Nady | en_US |
dc.contributor.author | Guillemin, Gilles | en_US |
dc.contributor.author | Grant, Ross | en_US |
dc.date.accessioned | 2021-11-25T12:37:44Z | |
dc.date.available | 2021-11-25T12:37:44Z | |
dc.date.issued | 2008 | en_US |
dc.description.abstract | Oxidative imbalance is a prominent feature in Alzheimer's disease and ageing. Increased levels of reactive oxygen species (ROS) can result in disordered cellular metabolism due to lipid peroxidation, protein-cross linking, DNA damage and the depletion of nicotinamide adenine dinucleotide (NAD+). NAD+ is a ubiquitous pyridine nucleotide that plays an essential role in important biological reactions, from ATP production and secondary messenger signalling, to transcriptional regulation and DNA repair. Chronic oxidative stress may be associated with NAD+ depletion and a subsequent decrease in metabolic regulation and cell viability. Hence, therapies targeted toward maintaining intracellular NAD+ pools may prove efficacious in the protection of age-dependent cellular damage, in general, and neurodegeneration in chronic central nervous system inflammatory diseases such as Alzheimer's disease, in particular. | en_US |
dc.identifier.issn | 1029-8428 | en_US |
dc.identifier.uri | http://hdl.handle.net/1959.4/34927 | |
dc.language | English | |
dc.language.iso | EN | en_US |
dc.rights | CC BY-NC-ND 3.0 | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/au/ | en_US |
dc.source | Legacy MARC | en_US |
dc.subject.other | oxidative stress | en_US |
dc.subject.other | NAD | en_US |
dc.subject.other | neurodegenerative | en_US |
dc.subject.other | Medical and Health Sciences not elsewhere classified (329999) | en_US |
dc.title | Promotion of Cellular NAD+ Anabolism: Therapeutic Potential for Oxidative Stress in Ageing and Alzheimer's Disease | en_US |
dc.type | Journal Article | en |
dcterms.accessRights | open access | |
dspace.entity.type | Publication | en_US |
unsw.accessRights.uri | https://purl.org/coar/access_right/c_abf2 | |
unsw.description.publisherStatement | Published version available via: http://www.fpgrahamco.com/nrjindex.php | en_US |
unsw.relation.faculty | Other UNSW | |
unsw.relation.faculty | Medicine & Health | |
unsw.relation.ispartofissue | 4 | en_US |
unsw.relation.ispartofjournal | Neurotoxicity Research | en_US |
unsw.relation.ispartofpagefrompageto | 173-184 | en_US |
unsw.relation.ispartofvolume | 13 | en_US |
unsw.relation.originalPublicationAffiliation | Braidy, Nady, Faculty of Medicine, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Guillemin, Gilles, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Grant, Ross, Medical Sciences, Faculty of Medicine, UNSW | en_US |
unsw.relation.school | School of Medical Sciences | * |
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