Publication:
Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters a1 and g1
Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters a1 and g1
dc.contributor.author | Out, R | en_US |
dc.contributor.author | Jessup, Wendy | en_US |
dc.contributor.author | Le Goff, W | en_US |
dc.contributor.author | Hoekstra, M | en_US |
dc.contributor.author | Gelissen, Ingrid | en_US |
dc.contributor.author | Zhao, Yong | en_US |
dc.contributor.author | Kritharides, Leonard | en_US |
dc.contributor.author | Chimini, G | en_US |
dc.contributor.author | Kuiper, J | en_US |
dc.contributor.author | Chapman, Matthew | en_US |
dc.contributor.author | Huby, T | en_US |
dc.contributor.author | Van Berkel, T | en_US |
dc.contributor.author | Van Eck, M | en_US |
dc.date.accessioned | 2021-11-25T12:49:33Z | |
dc.date.available | 2021-11-25T12:49:33Z | |
dc.date.issued | 2008 | en_US |
dc.description.abstract | The concept that macrophages can become foam cells as a result of a disturbed balance between the uptake of cholesterol from lipoproteins and cholesterol efflux is generally accepted. ABCA1 and ABCG1 are two cholesterol transporters that may act sequentially to remove cellular cholesterol, but currently their combined role in vivo is unknown. We report here that targeted disruption of both ABCA1 and ABCG1 in mice, despite severe plasma hypocholesterolemia, leads to massive lipid accumulation and foam cell formation of tissue macrophages. A complete ablation of cellular cholesterol efflux in vitro is observed, whereas in vivo macrophage-specific reverse cholesterol transport to the feces is markedly decreased. Despite the massive foam cell formation of tissue macrophages, no lipid accumulation was observed in the vascular wall, even in mice of 1 year old, indicating that the double knockout mice, possibly because of their hypocholesterolemia, lack the trigger to attract macrophages to the vessel wall. In conclusion, even under hypocholesterolemic conditions macrophages can be converted into foam cells, and ABCA1 and ABCG1 play an essential role in the prevention of foam cell formation. | en_US |
dc.identifier.issn | 0009-7330 | en_US |
dc.identifier.uri | http://hdl.handle.net/1959.4/38188 | |
dc.language | English | |
dc.language.iso | EN | en_US |
dc.rights | CC BY-NC-ND 3.0 | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/au/ | en_US |
dc.source | Legacy MARC | en_US |
dc.subject.other | cholesterol efflux | en_US |
dc.subject.other | ABC transporter | en_US |
dc.subject.other | reverse cholesterol transport | en_US |
dc.subject.other | macrophage | en_US |
dc.subject.other | foam cell | en_US |
dc.title | Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters a1 and g1 | en_US |
dc.type | Journal Article | en |
dcterms.accessRights | metadata only access | |
dspace.entity.type | Publication | en_US |
unsw.accessRights.uri | http://purl.org/coar/access_right/c_14cb | |
unsw.description.notePublic | The journal of Circulation Research is published by the American Heart Association Inc, http://www.americanheart.org/presenter.jhtml?identifier=1200000 | en_US |
unsw.description.publisherStatement | © 2008 American Heart Association, Inc. | en_US |
unsw.identifier.doiPublisher | http://dx.doi.org/10.1161/CIRCRESAHA.107.161711 | en_US |
unsw.relation.faculty | Medicine & Health | |
unsw.relation.faculty | Engineering | |
unsw.relation.faculty | Science | |
unsw.relation.ispartofjournal | Circulation Research | en_US |
unsw.relation.ispartofpagefrompageto | 113-120 | en_US |
unsw.relation.ispartofvolume | 102 | en_US |
unsw.relation.originalPublicationAffiliation | Out, R | en_US |
unsw.relation.originalPublicationAffiliation | Jessup, Wendy, Centre for Vascular Research, Faculty of Medicine, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Le Goff, W | en_US |
unsw.relation.originalPublicationAffiliation | Hoekstra, M | en_US |
unsw.relation.originalPublicationAffiliation | Gelissen, Ingrid, Centre for Vascular Research, Faculty of Medicine, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Zhao, Yong, Materials Science & Engineering, Faculty of Science, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Kritharides, Leonard, Centre for Vascular Research, Faculty of Medicine, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Chimini, G | en_US |
unsw.relation.originalPublicationAffiliation | Kuiper, J | en_US |
unsw.relation.originalPublicationAffiliation | Chapman, Matthew, Computer Science & Engineering, Faculty of Engineering, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Huby, T | en_US |
unsw.relation.originalPublicationAffiliation | Van Berkel, T | en_US |
unsw.relation.originalPublicationAffiliation | Van Eck, M | en_US |
unsw.relation.school | School of Medical Sciences | * |
unsw.relation.school | School of Materials Science & Engineering | * |
unsw.relation.school | School of Computer Science and Engineering | * |